{"id":"W4379374341","doi":"10.1101/2023.05.31.542971","title":"Albumin-binding RNAi Conjugate for Carrier Free Treatment of Arthritis","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; Vanderbilt University; Rheumatology Research Foundation; Congressionally Directed Medical Research Programs; Natural Sciences and Engineering Research Council of Canada; U.S. Department of Defense","keywords":"Rheumatoid arthritis; Gene silencing; Osteoarthritis; Inflammation; Arthritis; Medicine; Albumin; RNA interference; Pharmacology; Matrix metalloproteinase; Conjugate; Immunology; Internal medicine; Chemistry; Gene; Pathology; Biochemistry; RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003076659,0.0004108664,0.0002471157,0.0003301055,0.0001652614,0.0004004513,0.0002835274,0.0008030908,0.006658409],"category_scores_gemma":[0.0003478799,0.0001278455,0.0002004354,0.0001582919,0.0001688299,0.0004071493,0.0002148787,0.000646711,0.002471028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003052636,"about_ca_system_score_gemma":0.0002443835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001497453,"about_ca_topic_score_gemma":0.0002808971,"domain_scores_codex":[0.9998198,0.00003371112,0.00001804072,0.00003790297,0.00007593992,0.0000146429],"domain_scores_gemma":[0.9998697,0.0000266646,0.00002884926,0.000007404463,0.00004803318,0.00001933104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007039435,0.0001366589,0.0002234845,0.003923631,0.0001093142,0.0005506386,0.0001080274,0.0003313748,0.4969635,0.004666707,0.2532418,0.2390411],"study_design_scores_gemma":[0.0001180522,0.000520703,0.0005058608,0.00007758648,0.0000774404,0.0006736296,0.00001967353,0.0008217761,0.2195407,0.0004360198,0.7771875,0.0000210343],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1127366,0.4290034,0.09762793,0.02826747,0.2405544,0.001323862,0.001729298,0.004872673,0.08388435],"genre_scores_gemma":[0.3634466,0.1726191,0.02389497,0.01763169,0.04411528,0.0005589916,0.001785691,0.0008329555,0.3751149],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.006658409,"threshold_uncertainty_score":0.02227461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02252164758680885,"score_gpt":0.243707012024062,"score_spread":0.2211853644372531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}