{"id":"W4379376267","doi":"10.1080/03007995.2023.2219155","title":"Safety and efficacy of aripiprazole 2-month ready-to-use 960 mg: secondary analysis of outcomes in adult patients with bipolar I disorder in a randomized, open-label, parallel-arm, pivotal study","year":2023,"lang":"en","type":"article","venue":"Current Medical Research and Opinion","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brain and Cognition Discovery Foundation; University of Toronto","funders":"National Eye Institute; H. Lundbeck A/S; Otsuka Pharmaceutical","keywords":"Medicine; Aripiprazole; Tolerability; Clinical Global Impression; Adverse effect; Young Mania Rating Scale; Bipolar disorder; Bipolar I disorder; Randomized controlled trial; Clinical endpoint; Visual analogue scale; Internal medicine; Mania; Schizophrenia (object-oriented programming); Mood; Psychiatry; Anesthesia; Placebo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002244074,0.0001915084,0.001304672,0.001208316,0.00006491905,0.00002569584,0.0001801483,0.00009027497,0.00005681765],"category_scores_gemma":[0.002745142,0.0001216132,0.00005581669,0.00199892,0.0003417054,0.0001250949,0.000396259,0.0005438351,0.000003010934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004485981,"about_ca_system_score_gemma":0.0002383196,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003340541,"about_ca_topic_score_gemma":0.005773874,"domain_scores_codex":[0.9964821,0.00054445,0.0007625417,0.0004704695,0.001315881,0.0004246014],"domain_scores_gemma":[0.997479,0.001430519,0.00009433799,0.0003124106,0.0002353515,0.0004484261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03860426,0.009482631,0.8610123,0.0001518275,0.000607867,0.000008021395,0.001115995,0.00000262963,8.386596e-7,0.0000985783,0.00002610741,0.08888898],"study_design_scores_gemma":[0.2013493,0.002264603,0.7940864,0.0003538881,0.0001326214,3.276642e-7,0.0003713157,0.0007998212,9.794298e-7,0.00001775276,0.0005352078,0.00008776749],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992977,0.003254219,0.0000275376,0.0005872656,0.00005897471,0.0029501,0.00009680668,0.00001004018,0.00003806841],"genre_scores_gemma":[0.9909953,0.008233195,0.00004193585,0.00001300162,0.000008520125,0.0001553647,0.0005130711,0.0000146054,0.00002504565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1627451,"threshold_uncertainty_score":0.5049921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05695061033023321,"score_gpt":0.4097856326431164,"score_spread":0.3528350223128832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}