{"id":"W4379376476","doi":"10.1152/ajpcell.00080.2023","title":"Activating transcription factor 4 regulates mitochondrial content, morphology, and function in differentiating skeletal muscle myotubes","year":2023,"lang":"en","type":"article","venue":"American Journal of Physiology-Cell Physiology","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Government of Canada","keywords":"Myogenesis; Mitophagy; ATF4; Cell biology; Mitochondrial biogenesis; Mitochondrion; Biology; Transcription factor; mitochondrial fusion; Myocyte; C2C12; NRF1; Coactivator; Organelle biogenesis; PINK1; Autophagy; Unfolded protein response; Biogenesis; Biochemistry; Mitochondrial DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001518909,0.0002669778,0.0002676412,0.0002870833,0.0002283052,0.0002776281,0.0002093261,0.0002238255,0.001263449],"category_scores_gemma":[0.0001258245,0.0001449346,0.0003602645,0.0002523419,0.0001699383,0.0002137607,0.000212916,0.0004178974,0.0004794229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00043141,"about_ca_system_score_gemma":0.0002062436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001542823,"about_ca_topic_score_gemma":0.001715004,"domain_scores_codex":[0.9998865,0.00001471285,0.00001783669,0.0000285388,0.00002548204,0.00002680185],"domain_scores_gemma":[0.9999065,0.00001231757,0.000025704,0.000008533339,0.00002282453,0.00002408598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001675893,0.00002863326,0.0005163649,0.00003555591,0.000006176016,0.00003913799,0.00002063966,0.00003382163,0.9978486,0.00003846212,0.00005206655,0.001212909],"study_design_scores_gemma":[0.0000594261,0.0004114555,0.05653658,0.00002031603,0.00006722809,0.0003252574,0.0002015846,0.001950105,0.9347399,0.0001280856,0.005546961,0.00001314771],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905708,0.003931048,0.00234426,0.0001300601,0.0000447539,0.00002997931,0.0008812448,0.00007775285,0.001990073],"genre_scores_gemma":[0.986075,0.002293279,0.002455052,0.0001199375,0.00002026186,0.00007877494,0.001777638,0.00003567452,0.007144441],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001542823,"threshold_uncertainty_score":0.004226625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02386669058042041,"score_gpt":0.2589727559442253,"score_spread":0.2351060653638049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}