{"id":"W4379467212","doi":"10.1073/pnas.2220294120","title":"Polyvalent immunization elicits a synergistic broadly neutralizing immune response to hypervariable region 1 variants of hepatitis C virus","year":2023,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Hepatitis C virus research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto General Hospital","funders":"Centers for Disease Control and Prevention; University of Toronto","keywords":"Hypervariable region; Virology; Immunization; Biology; Antibody; Neutralizing antibody; Hepatitis C virus; Titer; Virus; Immune system; Vaccination; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004677066,0.000498395,0.000295661,0.0004045004,0.0001194198,0.0002767093,0.000281481,0.0004280846,0.0005913219],"category_scores_gemma":[0.000227424,0.0002078546,0.0002770921,0.0001235662,0.0003202045,0.0002223916,0.0003657434,0.00116499,0.0001677847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000287792,"about_ca_system_score_gemma":0.0001715792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001900458,"about_ca_topic_score_gemma":0.0005351739,"domain_scores_codex":[0.9995953,0.00009624479,0.00002266045,0.00008211796,0.0001020252,0.0001016268],"domain_scores_gemma":[0.9998615,0.0000407532,0.00002943211,0.00002338332,0.00001239336,0.00003250557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001988061,0.0002691011,0.0004938907,0.00003467856,0.00001974751,0.00002471779,0.0000211601,0.0006617263,0.9935722,0.0001494878,0.00006215469,0.004492319],"study_design_scores_gemma":[0.0002023532,0.01160741,0.01662066,0.00003366472,0.0001076543,0.0007513472,0.00008822569,0.01993187,0.9477485,0.0004758278,0.002408952,0.00002348933],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951138,0.0002565283,0.003329309,0.00004739832,0.00002654199,0.00004988113,0.00004960026,0.00004845547,0.001078495],"genre_scores_gemma":[0.996176,0.0001808439,0.002832235,0.0001093953,0.00001665336,0.00003187767,0.0001106492,0.000009226937,0.0005331517],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005913219,"threshold_uncertainty_score":0.002473474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08162141130728823,"score_gpt":0.3584443647941183,"score_spread":0.2768229534868301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}