{"id":"W4379467566","doi":"10.1016/s2468-1253(23)00141-3","title":"Performance of non-invasive tests and histology for the prediction of clinical outcomes in patients with non-alcoholic fatty liver disease: an individual participant data meta-analysis","year":2023,"lang":"en","type":"review","venue":"˜The œLancet. Gastroenterology & hepatology","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":187,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Novartis Pharma; Julius Clinical; Ipsen; Novo Nordisk; Eisai; University of Nottingham; Innovative Medicines Initiative; Novo Nordisk Fonden; Newcastle University; Korea Health Industry Development Institute; Abbott Laboratories; CSL Behring; National Institute for Health and Care Research; NIHR Newcastle Biomedical Research Centre; Innovative Health Initiative; Amryt Pharma; Royal Society; Fonds de Recherche du Québec - Santé; Intercept Pharmaceuticals; Eli Lilly and Company; Allergan; AstraZeneca; Wellcome Trust; Alexion Pharmaceuticals; Servier; Gilead Sciences; GlaxoSmithKline; NGM Biopharmaceuticals; Kowa Company; Inventiva Pharma; Pfizer; European Federation of Pharmaceutical Industries and Associations; Sanofi; Ministry of Health and Welfare","keywords":"Medicine; Internal medicine; Cirrhosis; Gastroenterology; Fatty liver; Transient elastography; Steatohepatitis; Clinical endpoint; Hepatic encephalopathy; Liver disease; Ascites; Stage (stratigraphy); Clinical trial; Disease; Liver fibrosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001001461,0.0005211805,0.007301661,0.0003534033,0.00009028615,0.000007294053,0.0008018861,0.0002879618,0.00001928388],"category_scores_gemma":[0.0001850615,0.0002544038,0.001071692,0.0003081585,0.0009674059,0.00008598484,0.0004591825,0.0004500906,0.000003384184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003357796,"about_ca_system_score_gemma":0.0003263999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00019828,"about_ca_topic_score_gemma":0.002705303,"domain_scores_codex":[0.9954925,0.0008254236,0.001744623,0.0009884579,0.0003065785,0.0006424005],"domain_scores_gemma":[0.9941201,0.002064864,0.001406123,0.002011619,0.0001851244,0.0002121225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001305275,0.001184182,0.8661124,0.002094823,0.1251074,0.00003227838,0.0000690766,0.000007092932,9.825726e-9,0.000002016617,0.0001864215,0.003898956],"study_design_scores_gemma":[0.00238124,0.002021878,0.6362678,0.0001331492,0.3578899,0.000008161684,0.000007847444,0.0006597484,3.650272e-8,0.000001238068,0.0005623675,0.00006654693],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7233399,0.2640291,0.00003642304,0.0004438584,0.0002367708,0.003951067,0.007938012,0.00002361918,0.000001200556],"genre_scores_gemma":[0.6054744,0.3899359,0.0001022256,0.0003495579,0.00007825004,0.00128376,0.002731983,0.00003821896,0.000005730587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2327825,"threshold_uncertainty_score":0.9999908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.333963645560395,"score_gpt":0.4189293496940114,"score_spread":0.08496570413361643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}