{"id":"W4379468088","doi":"10.1038/s41598-023-35826-w","title":"Oral micronized progesterone for perimenopausal night sweats and hot flushes a Phase III Canada-wide randomized placebo-controlled 4 month trial","year":2023,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Menopause: Health Impacts and Treatments","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Advancing Health Outcomes; Canadian Association of Gastroenterology; Etobicoke General Hospital; Institute of Population and Public Health; Women's Health Research Institute; University of British Columbia; University of British Columbia Hospital","funders":"Health Canada; University of British Columbia","keywords":"Medicine; Randomized controlled trial; Placebo; Bedtime; Randomization; Internal medicine; Adverse effect; Vasomotor; Gynecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009565704,0.0006944309,0.001408551,0.0003079606,0.0004135768,0.000616042,0.0006073594,0.001187516,0.005325406],"category_scores_gemma":[0.001042314,0.0003748508,0.0009905819,0.0003723642,0.0005488759,0.0002620074,0.0001886499,0.001330341,0.0004792547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001286576,"about_ca_system_score_gemma":0.002673634,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01348544,"about_ca_topic_score_gemma":0.043424,"domain_scores_codex":[0.9996551,0.0001581997,0.00001971808,0.00004944282,0.00004618583,0.00007131101],"domain_scores_gemma":[0.9995523,0.0001172139,0.0001128777,0.00002337484,0.00005176808,0.0001425752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9406299,0.00525977,0.0009418348,0.001918267,0.001202794,0.00005412276,0.00009266597,0.0002521198,0.004939876,0.0001642179,0.001830113,0.04271431],"study_design_scores_gemma":[0.9571954,0.03705794,0.003213522,0.0000998461,0.0003949982,0.00002776643,0.00003322705,0.0001701296,0.0003710274,0.0000869975,0.001339944,0.000009010898],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9636696,0.02245838,0.0005597302,0.001366299,0.0005489223,0.005898846,0.00184888,0.0001718723,0.003477446],"genre_scores_gemma":[0.9767123,0.0103477,0.001526736,0.001379235,0.0003065479,0.003744552,0.0008071227,0.00002002283,0.00515568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9865146,"threshold_uncertainty_score":0.02681386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03187987458314786,"score_gpt":0.3324653388520657,"score_spread":0.3005854642689179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}