{"id":"W4379468387","doi":"10.3390/ph16060837","title":"Annexin A5 Inhibits Endothelial Inflammation Induced by Lipopolysaccharide-Activated Platelets and Microvesicles via Phosphatidylserine Binding","year":2023,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa; Western University","funders":"Canadian Institutes of Health Research; American Heart Association","keywords":"Phosphatidylserine; Annexin; Microvesicles; Lipopolysaccharide; Inflammation; Platelet; Microvesicle; Sepsis; Platelet activation; Immunology; Cell biology; Annexin A5; Septic shock; Medicine; Biology; Flow cytometry; Biochemistry; microRNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002535183,0.0002131211,0.000177457,0.0000846152,0.0001378329,0.00005988318,0.0001215466,0.0001526581,0.00007576274],"category_scores_gemma":[0.00009328343,0.0002075689,0.00005101966,0.0001823404,0.00006430761,0.00002042081,0.0001643146,0.0001415303,0.0000899747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001387495,"about_ca_system_score_gemma":0.000025756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003273392,"about_ca_topic_score_gemma":0.00000415449,"domain_scores_codex":[0.9987428,0.00006141913,0.0002704183,0.0003975464,0.0001390624,0.0003888201],"domain_scores_gemma":[0.9995035,0.00002930043,0.00008719178,0.0001652246,0.00004697835,0.0001678174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000111423,0.0000289612,0.0002061121,0.00002514449,0.00005302527,0.000005911133,0.00004899843,0.000002598775,0.9733363,0.00002780148,0.0007544428,0.02539933],"study_design_scores_gemma":[0.0009501986,0.00009728358,0.0001547105,0.00001905589,0.00001458796,0.00001252533,0.00003347974,0.0003348221,0.9766216,0.00006116416,0.02145007,0.0002505021],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982416,0.0002925264,0.0001198377,0.0005840859,0.0001256561,0.0003351571,0.00009717338,0.00008994445,0.0001139967],"genre_scores_gemma":[0.9982906,0.0004967771,0.0001012544,0.0003224704,0.0002140689,0.00004637719,0.0002566271,0.00004085539,0.0002309883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02514882,"threshold_uncertainty_score":0.8464412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02471421528832814,"score_gpt":0.3034892868638338,"score_spread":0.2787750715755057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}