{"id":"W4379468387","doi":"10.3390/ph16060837","title":"Annexin A5 Inhibits Endothelial Inflammation Induced by Lipopolysaccharide-Activated Platelets and Microvesicles via Phosphatidylserine Binding","year":2023,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa; Western University","funders":"Canadian Institutes of Health Research; American Heart Association","keywords":"Phosphatidylserine; Annexin; Microvesicles; Lipopolysaccharide; Inflammation; Platelet; Microvesicle; Sepsis; Platelet activation; Immunology; Cell biology; Annexin A5; Septic shock; Medicine; Biology; Flow cytometry; Biochemistry; microRNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001090273,0.0002567471,0.0002058558,0.0001791306,0.00010381,0.0001954003,0.0001552804,0.0002611926,0.001099102],"category_scores_gemma":[0.000104221,0.00006775267,0.0002175631,0.0000913296,0.000148985,0.000169659,0.00013303,0.0004572824,0.0001609376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001754238,"about_ca_system_score_gemma":0.000204172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005367164,"about_ca_topic_score_gemma":0.0005945386,"domain_scores_codex":[0.9999268,0.00001819925,0.000008822079,0.00001039486,0.00001741716,0.00001832068],"domain_scores_gemma":[0.9999642,0.000007002888,0.000009492218,0.000002935122,0.000004679566,0.00001164265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000756758,0.0002568674,0.0001497023,0.0001345683,0.00002679554,0.0000629189,0.00002314363,0.0001766539,0.9926043,0.0002721402,0.0001449915,0.005391253],"study_design_scores_gemma":[0.0003405028,0.00594498,0.005929451,0.00003428008,0.00007382084,0.0003573226,0.00004665303,0.002885422,0.9789323,0.0001776952,0.00526635,0.00001121043],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931022,0.003258741,0.002039547,0.000129951,0.00005648313,0.00004319698,0.0001133894,0.0000804586,0.001176074],"genre_scores_gemma":[0.9958688,0.001196816,0.00119817,0.00008433221,0.00001373985,0.00002600362,0.0002600314,0.000005828118,0.001346212],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001099102,"threshold_uncertainty_score":0.003676891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02471421528832814,"score_gpt":0.3034892868638338,"score_spread":0.2787750715755057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}