{"id":"W4379470153","doi":"10.3390/md21060347","title":"The Anti-Inflammatory Effect of Low Molecular Weight Fucoidan from Sargassum siliquastrum in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages via Inhibiting NF-κB/MAPK Signaling Pathways","year":2023,"lang":"en","type":"article","venue":"Marine Drugs","topic":"Seaweed-derived Bioactive Compounds","field":"Agricultural and Biological Sciences","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Korea Institute of Marine Science and Technology promotion; Ministry of Oceans and Fisheries","keywords":"Fucoidan; Lipopolysaccharide; Inflammasome; MAPK/ERK pathway; NF-κB; Chemistry; Signal transduction; Macrophage; Tumor necrosis factor alpha; Proinflammatory cytokine; Reactive oxygen species; Viability assay; Cell biology; Inflammation; Biology; Biochemistry; Polysaccharide; Apoptosis; Immunology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009131079,0.0003471531,0.0001875399,0.0001404087,0.00008254154,0.0001029045,0.00008406791,0.0001605636,0.0003673732],"category_scores_gemma":[0.00005415007,0.0000694777,0.0002468963,0.00009378845,0.0001297185,0.0001621702,0.0001256824,0.0002590874,0.00006512796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009420678,"about_ca_system_score_gemma":0.0001655254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004412481,"about_ca_topic_score_gemma":0.0007218056,"domain_scores_codex":[0.9999716,0.000005991828,0.000003462464,0.000004088473,0.000007076116,0.000007758899],"domain_scores_gemma":[0.9999747,0.000003024757,0.000009062626,0.000002127772,0.000004447144,0.000006660679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002346153,0.00002524265,0.00009724853,0.00007988505,0.000005652004,0.00003976676,0.00001250578,0.0000534754,0.9978485,0.00001880454,0.00001634552,0.001567948],"study_design_scores_gemma":[0.0000421262,0.001449531,0.006339777,0.00001365352,0.00003493298,0.0001968536,0.00004077517,0.0006322213,0.9896853,0.00004393176,0.001514412,0.00000653629],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964864,0.002019223,0.0008436877,0.0000613359,0.00001672435,0.00001356282,0.00009389052,0.00002003113,0.0004451093],"genre_scores_gemma":[0.9964995,0.001220914,0.001159802,0.00006215794,0.00001067274,0.00001771538,0.0001836906,0.000003725171,0.0008417331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004412481,"threshold_uncertainty_score":0.001228988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004933621217830747,"score_gpt":0.1960627264018243,"score_spread":0.1911291051839936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}