{"id":"W4379473222","doi":"10.3390/curroncol30060413","title":"Treatment Settings and Outcomes with Regorafenib and Trifluridine/Tipiracil at Third-Line Treatment and beyond in Metastatic Colorectal Cancer: A Real-World Multicenter Retrospective Study","year":2023,"lang":"en","type":"article","venue":"Current Oncology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Regorafenib; Internal medicine; Colorectal cancer; Neutropenia; Gastroenterology; Progression-free survival; Refractory (planetary science); Oncology; Overall survival; Chemotherapy; Cancer","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001168209,0.0002479678,0.0005952544,0.0005938621,0.0004410969,0.000790367,0.0003628941,0.0005266864,0.0007918378],"category_scores_gemma":[0.002375872,0.0002291464,0.0007967155,0.001235374,0.0003929269,0.0004636346,0.0004041275,0.0004864974,0.0001817848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008302468,"about_ca_system_score_gemma":0.0005122122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001744721,"about_ca_topic_score_gemma":0.001938927,"domain_scores_codex":[0.9985594,0.0004851684,0.0002051167,0.0003514327,0.0002151269,0.0001838002],"domain_scores_gemma":[0.9968247,0.0003064228,0.002172043,0.00017254,0.0001665077,0.0003578584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001249646,0.0001137706,0.9962243,0.00003089966,0.0001682901,0.0002158357,0.00005488476,0.00007595145,0.0002078558,0.00001460817,0.0001025902,0.00154135],"study_design_scores_gemma":[0.0001239954,0.001070894,0.9960784,0.00001408793,0.0002114981,0.001344405,0.0002274,0.0002022812,0.0001375657,0.00002260783,0.0005533791,0.00001351088],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986265,0.0008078688,0.00005059431,0.00002151729,0.000004011011,0.00002076152,0.0002403388,0.00000173792,0.0002266967],"genre_scores_gemma":[0.9993873,0.0001522618,0.00004642084,0.00002753703,0.00001056656,0.00002002896,0.0003208186,0.000001546563,0.00003343211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001744721,"threshold_uncertainty_score":0.006178141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07028040667354266,"score_gpt":0.4089968264603842,"score_spread":0.3387164197868415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}