{"id":"W4379473385","doi":"10.3390/cells12111538","title":"RANKL Inhibition Reduces Cardiac Hypertrophy in mdx Mice and Possibly in Children with Duchenne Muscular Dystrophy","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; University of Ottawa; Children's Hospital of Eastern Ontario; University of Waterloo; Centre hospitalier de l'Université Laval; Centre hospitalier universitaire de Québec","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Ottawa","keywords":"RANKL; Duchenne muscular dystrophy; Endocrinology; Internal medicine; Medicine; Muscle hypertrophy; Osteoprotegerin; Cardiac function curve; Muscular dystrophy; Dystrophin; Myocyte; Activator (genetics); Receptor; Heart failure","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001717,0.0004602995,0.0004486882,0.0003867318,0.0001490053,0.0001813761,0.0001838293,0.0004153108,0.001577473],"category_scores_gemma":[0.0001157309,0.0001555737,0.0002191888,0.0001371811,0.0002462648,0.000153787,0.0001686352,0.000805157,0.000276419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002090118,"about_ca_system_score_gemma":0.0002599816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005998088,"about_ca_topic_score_gemma":0.001869781,"domain_scores_codex":[0.9998567,0.00003091055,0.00001524351,0.00002928277,0.00003830497,0.0000295749],"domain_scores_gemma":[0.9998689,0.00001285362,0.0000415651,0.000005613065,0.000008448756,0.00006261166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001251656,0.0004784057,0.001324423,0.0001783325,0.00003327643,0.0002348784,0.00006391569,0.0001181753,0.9876629,0.0001095671,0.0002941945,0.00825033],"study_design_scores_gemma":[0.0009848395,0.01294275,0.1324451,0.0001190344,0.0001954142,0.002165958,0.0003097939,0.001156179,0.8304812,0.0002199392,0.01894834,0.0000314073],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925316,0.004368055,0.0006738434,0.0002900122,0.00003668988,0.00003528284,0.0006525859,0.000131167,0.001280679],"genre_scores_gemma":[0.9888937,0.002978175,0.0018093,0.0002383303,0.00002573093,0.0001158228,0.0009812498,0.00002720072,0.004930515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001577473,"threshold_uncertainty_score":0.005277157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003111600318284863,"score_gpt":0.189650907562606,"score_spread":0.1865393072443211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}