{"id":"W4379507871","doi":"10.7554/elife.82483","title":"Mec1-independent activation of the Rad53 checkpoint kinase revealed by quantitative analysis of protein localization dynamics","year":2023,"lang":"en","type":"article","venue":"eLife","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Canadian Institutes of Health Research; Government of Ontario","keywords":"G2-M DNA damage checkpoint; DNA replication; Cell biology; Biology; Checkpoint Kinase 2; Origin recognition complex; DNA damage; Saccharomyces cerevisiae; Origin of replication; Cell Cycle Protein; Kinase; Protein kinase A; Cell cycle checkpoint; Eukaryotic DNA replication; Genetics; Cell cycle; DNA; Gene; Protein-Serine-Threonine Kinases","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000076617,0.0002188779,0.00009579645,0.0001727922,0.00008538484,0.0001759644,0.0001506699,0.0001370143,0.001099953],"category_scores_gemma":[0.0001093393,0.0001025826,0.0001411041,0.0001081258,0.0001885659,0.0001571585,0.0001447432,0.0002708231,0.0003004817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003298108,"about_ca_system_score_gemma":0.0001230846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005006028,"about_ca_topic_score_gemma":0.000894614,"domain_scores_codex":[0.9999372,0.000006589226,0.000003789421,0.00001969458,0.00001696002,0.00001577123],"domain_scores_gemma":[0.9999348,0.000009363281,0.00002134945,0.00001185647,0.000009433569,0.00001317106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004798394,0.000003581624,0.0002262458,0.0000111345,0.000001441493,0.00001224499,0.000003839174,0.00002272945,0.9990466,0.00006093284,0.000007917452,0.0005553769],"study_design_scores_gemma":[0.000002984133,0.00003349967,0.009586724,0.000002267184,0.000003616764,0.0001160165,0.00001219419,0.0008003697,0.9889599,0.00005984881,0.0004201347,0.000002484083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941638,0.0008106416,0.003723301,0.0000423214,0.00001047004,0.000008967889,0.0004107193,0.00006117013,0.0007686819],"genre_scores_gemma":[0.9968059,0.0002891806,0.00133785,0.00001176357,0.00000247463,0.00001400107,0.0003066369,0.00001775534,0.00121444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001099953,"threshold_uncertainty_score":0.003679693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01002294098764016,"score_gpt":0.2591895682246831,"score_spread":0.2491666272370429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}