{"id":"W4379507891","doi":"10.1002/cac2.12447","title":"Predictive power of tertiary lymphoid structure signature for neoadjuvant chemotherapy response and immunotherapy benefit in HER2‐negative breast cancer","year":2023,"lang":"en","type":"letter","venue":"Cancer Communications","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nautical Research Society","funders":"Ligue Contre le Cancer","keywords":"Oncology; Medicine; Internal medicine; Breast cancer; Pembrolizumab; Cancer; Predictive marker; Immunotherapy; Gene signature; Biology; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002077011,0.0002948922,0.0008225039,0.0005944567,0.0002907313,0.001047845,0.0006290748,0.001576391,0.002537835],"category_scores_gemma":[0.008178266,0.0001524594,0.00030969,0.000349708,0.0006502725,0.0007941683,0.0003754917,0.002261123,0.0009650697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002628686,"about_ca_system_score_gemma":0.0003009645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001860671,"about_ca_topic_score_gemma":0.0003215582,"domain_scores_codex":[0.9994678,0.0001465794,0.0001055254,0.0001042049,0.000109517,0.00006633926],"domain_scores_gemma":[0.996169,0.001996642,0.0005112856,0.0001358599,0.0008391563,0.0003481477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.006620334,0.0003031523,0.1044676,0.002733856,0.000421518,0.009148005,0.0003699791,0.0006171289,0.01236086,0.001853919,0.6211631,0.2399406],"study_design_scores_gemma":[0.0006376808,0.001403602,0.1376059,0.001306044,0.001361286,0.04417716,0.0009267854,0.01153352,0.01341171,0.005116079,0.7823069,0.0002133321],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.1810968,0.1317454,0.006397911,0.4581989,0.2125098,0.0002183471,0.003313471,0.0002948256,0.00622446],"genre_scores_gemma":[0.5064526,0.0367647,0.004263127,0.08261821,0.3578666,0.0001624557,0.001419427,0.0002077163,0.01024517],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002537835,"threshold_uncertainty_score":0.01098442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0151065744381033,"score_gpt":0.3030426649719141,"score_spread":0.2879360905338108,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}