{"id":"W4379507891","doi":"10.1002/cac2.12447","title":"Predictive power of tertiary lymphoid structure signature for neoadjuvant chemotherapy response and immunotherapy benefit in HER2‐negative breast cancer","year":2023,"lang":"en","type":"letter","venue":"Cancer Communications","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nautical Research Society","funders":"Ligue Contre le Cancer","keywords":"Oncology; Medicine; Internal medicine; Breast cancer; Pembrolizumab; Cancer; Predictive marker; Immunotherapy; Gene signature; Biology; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003172308,0.000549862,0.0009669085,0.0003860776,0.000183922,0.00003403037,0.0007647692,0.001018665,0.0004855844],"category_scores_gemma":[0.00003909407,0.0004896055,0.0003138608,0.0006705408,0.0007405426,0.0001261597,0.0001443896,0.001437687,9.966967e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009480573,"about_ca_system_score_gemma":0.001034729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003869819,"about_ca_topic_score_gemma":0.001719356,"domain_scores_codex":[0.9976009,0.0002301578,0.0007470516,0.0006078154,0.0003439944,0.0004701294],"domain_scores_gemma":[0.9961127,0.0008347515,0.0005558805,0.001971722,0.0004547167,0.00007025107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.05359428,0.0003719262,0.01356523,0.001052183,0.005209707,0.00003405659,0.01293802,0.00007696559,0.05098967,0.00001794543,0.7856518,0.0764982],"study_design_scores_gemma":[0.01845757,0.0007833975,0.422423,0.005819391,0.000491975,0.0001352543,0.001072678,0.0004499287,0.003769284,0.0009207083,0.5444308,0.001246005],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.06467249,0.06679438,0.00003013513,0.8416619,0.0006316084,0.003848498,0.02215691,0.0001350803,0.00006900874],"genre_scores_gemma":[0.2134944,0.180375,0.001802196,0.5862154,0.001539394,0.006246928,0.002965494,0.0008286432,0.006532629],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.4088578,"threshold_uncertainty_score":0.9997556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0151065744381033,"score_gpt":0.3030426649719141,"score_spread":0.2879360905338108,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}