{"id":"W4379509021","doi":"10.1007/s11523-023-00965-7","title":"A Phase Ib Study Assessing the Safety, Tolerability, and Efficacy of the First-in-Class Wee1 Inhibitor Adavosertib (AZD1775) as Monotherapy in Patients with Advanced Solid Tumors","year":2023,"lang":"en","type":"article","venue":"Targeted Oncology","topic":"Insect Resistance and Genetics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Alberta","funders":"AstraZeneca","keywords":"Medicine; Tolerability; Oncology; Internal medicine; Pharmacology; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003452564,0.0001818921,0.0003260627,0.00006770404,0.0001225036,0.00001319599,0.000249017,0.0001333258,0.000007317822],"category_scores_gemma":[0.0001130048,0.0001143411,0.00004764421,0.0004006394,0.0001905471,0.00000692736,0.0001507061,0.0001919403,0.000001528695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006290409,"about_ca_system_score_gemma":0.0002208444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006135314,"about_ca_topic_score_gemma":0.00236733,"domain_scores_codex":[0.998477,0.0002398804,0.0004230568,0.0003680984,0.0001706375,0.00032132],"domain_scores_gemma":[0.9991884,0.00009686709,0.0001783461,0.0004152684,0.00008384055,0.00003726779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007936421,0.006577733,0.8490409,0.00005984505,0.000150528,0.00003304987,0.004203178,0.003320154,0.1040923,0.00001844778,0.0002853156,0.02428217],"study_design_scores_gemma":[0.0157697,0.006249114,0.9467859,0.00004608737,0.00002114127,0.000001860878,0.0009924195,0.0001302508,0.02639379,0.00008093577,0.003321067,0.000207719],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979107,0.0001728387,0.000005911886,0.0005769197,0.000129684,0.001034497,0.0000106651,0.00000955532,0.0001492747],"genre_scores_gemma":[0.9994047,0.00004237734,0.00005294228,0.0003003879,0.00004426927,0.00005785364,0.00002560985,0.0000228661,0.00004897271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09774502,"threshold_uncertainty_score":0.4662696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007141951924465786,"score_gpt":0.3043287191005847,"score_spread":0.2971867671761189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}