{"id":"W4379509021","doi":"10.1007/s11523-023-00965-7","title":"A Phase Ib Study Assessing the Safety, Tolerability, and Efficacy of the First-in-Class Wee1 Inhibitor Adavosertib (AZD1775) as Monotherapy in Patients with Advanced Solid Tumors","year":2023,"lang":"en","type":"article","venue":"Targeted Oncology","topic":"Insect Resistance and Genetics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Alberta","funders":"AstraZeneca","keywords":"Medicine; Tolerability; Oncology; Internal medicine; Pharmacology; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001301895,0.001063084,0.001705956,0.0003320964,0.0004312155,0.0008101175,0.0005652854,0.0007598918,0.003422021],"category_scores_gemma":[0.0006636727,0.0004177864,0.0009374303,0.0003973654,0.0006928348,0.0006523038,0.0002748957,0.002319595,0.0008923427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008054909,"about_ca_system_score_gemma":0.001833967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006661885,"about_ca_topic_score_gemma":0.001367033,"domain_scores_codex":[0.9996588,0.0001373418,0.00002194351,0.00006199325,0.00003765848,0.00008224638],"domain_scores_gemma":[0.9992756,0.00009354044,0.0001302193,0.00005979912,0.00004969208,0.0003911508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6225053,0.121964,0.0142733,0.001425575,0.001436378,0.0005186537,0.0004160728,0.003005425,0.1084762,0.0003070601,0.003729159,0.1219429],"study_design_scores_gemma":[0.2938319,0.6843798,0.01228022,0.00003305457,0.0003538246,0.0003875467,0.00006997832,0.000898512,0.004950139,0.0001392509,0.002656743,0.00001922036],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993811,0.001305836,0.0004107186,0.0001690748,0.0000692341,0.002182351,0.000718371,0.00004349329,0.001290027],"genre_scores_gemma":[0.9917167,0.001164102,0.00117236,0.000439547,0.0001089489,0.002014798,0.002015742,0.00001915327,0.00134866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003422021,"threshold_uncertainty_score":0.01144779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007141951924465786,"score_gpt":0.3043287191005847,"score_spread":0.2971867671761189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}