{"id":"W4379509235","doi":"10.1007/7651_2023_487","title":"Single-Cell mRNA-sncRNA Co-sequencing of Preimplantation Embryos","year":2023,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Hospital; University of Toronto; Université de Montréal; CReATe Fertility Centre; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Biology; Computational biology; RNA; Embryo; Embryonic stem cell; Cell; Deep sequencing; Genetics; Single-cell analysis; Cell biology; Gene; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000928865,0.0002007936,0.0003091834,0.0002152097,0.0000382095,0.000009303188,0.000274437,0.0003455237,0.00001290371],"category_scores_gemma":[0.0002474562,0.0002047777,0.0001353847,0.0003306845,0.0001448483,0.000003108171,0.00007452066,0.0001555014,0.000008786276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002932728,"about_ca_system_score_gemma":0.00008680904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007248351,"about_ca_topic_score_gemma":0.00001979748,"domain_scores_codex":[0.9979265,0.0007065742,0.0004495073,0.0004559424,0.00008499439,0.0003764468],"domain_scores_gemma":[0.9992726,0.0000904137,0.0001486346,0.0003638954,0.00006543849,0.00005902758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007436969,0.0000538132,0.003894713,0.00005099393,0.00002802325,0.00001573015,0.00009813174,0.000313819,0.9887203,0.0001751749,0.00005421778,0.00652069],"study_design_scores_gemma":[0.0006685025,0.0003956951,0.0003901172,0.00001639167,0.00001674106,0.00001542947,0.00008017013,0.000385315,0.9948493,0.0009592356,0.002007427,0.000215684],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6448286,0.0003214267,0.3524176,0.00002904109,0.0002663399,0.0001837694,0.00002250409,0.00002722268,0.001903456],"genre_scores_gemma":[0.7109919,0.0001982622,0.2876694,0.0002638962,0.00009034209,0.0000373547,0.000427475,0.00005427642,0.0002671432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06616328,"threshold_uncertainty_score":0.8350593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04435276900807925,"score_gpt":0.3622381608149417,"score_spread":0.3178853918068625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}