{"id":"W4379517387","doi":"10.1136/annrheumdis-2023-eular.673","title":"OP0102 IDENTIFICATION OF NEW RISK LOCI AND PATHWAYS INVOLVED IN GCA PATHOGENESIS BY A GENOME-WIDE STUDY","year":2023,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Otitis Media and Relapsing Polychondritis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Firenze; Universitätsklinikum Erlangen; Universitat Autònoma de Barcelona; Université Paris Descartes; Università degli Studi di Ferrara; Assistance publique-Hôpitaux de Paris; Université Paris Diderot; Medizinischen Hochschule Hannover; Université de Toulouse; McMaster University; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico; Institut National de la Santé et de la Recherche Médicale; Universitat de Barcelona; Cleveland Clinic","keywords":"Giant cell arteritis; Genome-wide association study; Imputation (statistics); Medicine; DrugBank; Disease; Genetic association; Genetics; Bioinformatics; Vasculitis; Biology; Gene; Internal medicine; Genotype; Single-nucleotide polymorphism; Missing data","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002794511,0.0001194279,0.0003822448,0.0001545363,0.00005104512,0.00001339562,0.0001465568,0.00004441382,0.00002271793],"category_scores_gemma":[0.00126134,0.00008618421,0.0001172205,0.0004707233,0.00011229,0.0000588718,0.00007639521,0.00006840801,0.00001118621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008714715,"about_ca_system_score_gemma":0.0001089275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003562644,"about_ca_topic_score_gemma":0.00005464318,"domain_scores_codex":[0.9985959,0.0001380842,0.0005650342,0.0001880751,0.0003390141,0.000173908],"domain_scores_gemma":[0.9988345,0.0002195471,0.0003230537,0.0004115608,0.00006549147,0.0001458516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00008963572,0.000965879,0.938696,0.000634683,0.0002226981,0.00001220341,0.004872624,0.00002441006,0.002667651,0.0000134726,0.02928521,0.02251557],"study_design_scores_gemma":[0.001124379,0.0001634999,0.9922416,0.0005270889,0.0002140808,0.000001269025,0.002585951,0.0001340794,0.001641029,0.001163082,0.0001160923,0.00008787398],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934756,0.004510552,0.00001248777,0.0008032746,0.0003677589,0.000611163,0.0001733799,0.00003087397,0.00001489712],"genre_scores_gemma":[0.9927984,0.005778694,0.00001684508,0.00007097159,0.0000140078,0.00002588925,0.00004429815,0.00001911582,0.001231805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05354562,"threshold_uncertainty_score":0.351449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03713372747023067,"score_gpt":0.2901133921053561,"score_spread":0.2529796646351254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}