{"id":"W4379517387","doi":"10.1136/annrheumdis-2023-eular.673","title":"OP0102 IDENTIFICATION OF NEW RISK LOCI AND PATHWAYS INVOLVED IN GCA PATHOGENESIS BY A GENOME-WIDE STUDY","year":2023,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Otitis Media and Relapsing Polychondritis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Firenze; Universitätsklinikum Erlangen; Universitat Autònoma de Barcelona; Université Paris Descartes; Università degli Studi di Ferrara; Assistance publique-Hôpitaux de Paris; Université Paris Diderot; Medizinischen Hochschule Hannover; Université de Toulouse; McMaster University; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico; Institut National de la Santé et de la Recherche Médicale; Universitat de Barcelona; Cleveland Clinic","keywords":"Giant cell arteritis; Genome-wide association study; Imputation (statistics); Medicine; DrugBank; Disease; Genetic association; Genetics; Bioinformatics; Vasculitis; Biology; Gene; Internal medicine; Genotype; Single-nucleotide polymorphism; Missing data","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007088535,0.0008455649,0.0007493275,0.00115343,0.000640591,0.001456776,0.0005769889,0.0008765557,0.004411011],"category_scores_gemma":[0.001218781,0.0003063768,0.002037358,0.002584605,0.0004010075,0.0003671423,0.0009093977,0.001132985,0.0005447185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003056317,"about_ca_system_score_gemma":0.0007109484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004763932,"about_ca_topic_score_gemma":0.005171309,"domain_scores_codex":[0.9995077,0.00007283988,0.00004422684,0.0001944512,0.0000801374,0.0001005869],"domain_scores_gemma":[0.9992909,0.0002684162,0.0002016839,0.00004738049,0.00007190685,0.0001195464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006763077,0.0002758241,0.8809053,0.00121076,0.007881572,0.00591178,0.0004493897,0.001278824,0.05097661,0.001049588,0.005559775,0.03773765],"study_design_scores_gemma":[0.0003727584,0.0002633363,0.9795977,0.0001100869,0.004604195,0.002343551,0.0002803589,0.001507235,0.002163164,0.0008194212,0.007890995,0.00004718574],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9767907,0.007931767,0.002260166,0.0008638795,0.0002043256,0.00006254189,0.008910487,0.00009505574,0.002880973],"genre_scores_gemma":[0.9862856,0.002224209,0.001903696,0.0004425856,0.0001918944,0.00006816472,0.006874576,0.00005583168,0.00195347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004763932,"threshold_uncertainty_score":0.01475632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03713372747023067,"score_gpt":0.2901133921053561,"score_spread":0.2529796646351254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}