{"id":"W4379517809","doi":"10.1136/annrheumdis-2023-eular.6049","title":"POS0332 IDENTIFICATION OF DISTINCT CELLULAR POPULATIONS IN THE SYNOVIUM OF EARLY- AND LATE-STAGE RADIOGRAPHIC KNEE OA USING SINGLE NUCLEUS RNA SEQUENCING","year":2023,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Musculoskeletal synovial abnormalities and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Arthritis Society","funders":"","keywords":"Medicine; RNA; Radiography; Stage (stratigraphy); Nucleus; Biology; Genetics; Surgery; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002725523,0.0001055521,0.0002801786,0.0001577519,0.00008477626,0.00001487121,0.0001185932,0.00002897112,0.00001472665],"category_scores_gemma":[0.0002168496,0.00006547274,0.0001925408,0.0005940797,0.0001719834,0.00009966322,0.00005499518,0.00004223648,0.000001034789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001380034,"about_ca_system_score_gemma":0.00003323393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002317955,"about_ca_topic_score_gemma":0.00002901405,"domain_scores_codex":[0.9987945,0.0001096545,0.0005276492,0.0001168708,0.0003019674,0.0001493808],"domain_scores_gemma":[0.9990367,0.0001288796,0.0003594849,0.0003552586,0.00007264208,0.0000470241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002458207,0.001355819,0.9374681,0.0058725,0.0007592208,0.00002613363,0.005130073,0.00241561,0.03354399,0.004240297,0.00006553005,0.008876942],"study_design_scores_gemma":[0.0003807828,0.0001203982,0.9904413,0.0007992199,0.0002494896,0.000001626429,0.0006954616,0.003236932,0.001925442,0.002078302,0.000002982122,0.00006803162],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998518,0.0005134412,0.00002109907,0.0002512036,0.00005910213,0.0003999294,0.0001437921,0.00001329702,0.00008008271],"genre_scores_gemma":[0.9997662,0.00005922865,0.00002645899,0.00001695953,0.000008268854,0.000008560723,0.00003653183,0.00001217052,0.0000656444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05297326,"threshold_uncertainty_score":0.3504071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1094594257072926,"score_gpt":0.3277247090309512,"score_spread":0.2182652833236587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}