{"id":"W4379517809","doi":"10.1136/annrheumdis-2023-eular.6049","title":"POS0332 IDENTIFICATION OF DISTINCT CELLULAR POPULATIONS IN THE SYNOVIUM OF EARLY- AND LATE-STAGE RADIOGRAPHIC KNEE OA USING SINGLE NUCLEUS RNA SEQUENCING","year":2023,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Musculoskeletal synovial abnormalities and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Arthritis Society","funders":"","keywords":"Medicine; RNA; Radiography; Stage (stratigraphy); Nucleus; Biology; Genetics; Surgery; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003766031,0.0002694046,0.0003787171,0.0005436901,0.0004661548,0.0008095826,0.0002425187,0.0005612043,0.002734007],"category_scores_gemma":[0.0005764612,0.0002180836,0.0004230513,0.0003603332,0.0003188241,0.0002083381,0.0002833501,0.0004448453,0.001277813],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002275483,"about_ca_system_score_gemma":0.0003469411,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000742492,"about_ca_topic_score_gemma":0.002535016,"domain_scores_codex":[0.9995977,0.00004966142,0.00003529888,0.0001244069,0.0001265964,0.00006644501],"domain_scores_gemma":[0.9997231,0.00007396776,0.0000461204,0.0000314626,0.00009062295,0.00003474471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002896172,0.00001602196,0.00419673,0.00007072671,0.00001652021,0.00008000687,0.00007724764,0.0001089051,0.9892486,0.0001212358,0.000169702,0.005604707],"study_design_scores_gemma":[0.0001642863,0.001377557,0.244334,0.000149206,0.000244159,0.002174959,0.001221751,0.01011692,0.7199118,0.001142145,0.01910068,0.00006259713],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9707609,0.001377702,0.01791573,0.0002476576,0.0001839643,0.0000998886,0.004785881,0.0002638529,0.004364374],"genre_scores_gemma":[0.9660419,0.0006586745,0.01951618,0.0005624469,0.00006588133,0.0002708705,0.006655337,0.0001928701,0.006035961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002734007,"threshold_uncertainty_score":0.009146154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1094594257072926,"score_gpt":0.3277247090309512,"score_spread":0.2182652833236587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}