{"id":"W4379519347","doi":"10.1136/annrheumdis-2023-eular.751","title":"OP0075 EFFICACY, SAFETY, PHARMACOKINETICS AND IMMUNOGENICITY OF REPEATED DOSING OF GSK3858279 IN PATIENTS WITH KNEE OSTEOARTHRITIS: A PHASE I, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY","year":2023,"lang":"en","type":"article","venue":"","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Faculty of Health and Medical Sciences, University of Western Australia; Medical University - Varna; Universidade Nova de Lisboa; Keele University; lékařská fakulta Univerzity Karlovy; Lunds Universitet; Leids Universitair Medisch Centrum; Regeneron Pharmaceuticals; Universiteit Leiden; University of Limerick; Vrije Universiteit Brussel; University of Leeds; Eli Lilly and Company; AstraZeneca; Medical University Sofia; University of Surrey; Pfizer; Stryker; Høgskulen på Vestlandet; Univerzita Karlova v Praze","keywords":"Medicine; WOMAC; Osteoarthritis; Placebo; Clinical endpoint; Internal medicine; Adverse effect; Physical therapy; Dosing; CCL17; Randomized controlled trial; Inflammation; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001495045,0.001276365,0.002482804,0.0004050485,0.0003781194,0.0008940796,0.0008064079,0.001555054,0.006813431],"category_scores_gemma":[0.001151202,0.0006008255,0.001868826,0.0004733153,0.0009030633,0.001007573,0.0002953406,0.002410536,0.001199022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006063692,"about_ca_system_score_gemma":0.001264655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006562183,"about_ca_topic_score_gemma":0.001801578,"domain_scores_codex":[0.9994979,0.0002032034,0.00004301161,0.00008385567,0.00007794035,0.00009406243],"domain_scores_gemma":[0.9992245,0.0001748915,0.0002416038,0.00005479283,0.00006946844,0.0002347019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9116396,0.02466623,0.001366452,0.00181764,0.001366011,0.0001252076,0.0001047635,0.0005225411,0.01407999,0.0001056749,0.001821486,0.04238444],"study_design_scores_gemma":[0.7211959,0.2707211,0.005104014,0.00005658766,0.0005654221,0.00007801079,0.00004559391,0.0003898262,0.0008937145,0.00008866952,0.0008338387,0.00002725982],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850167,0.006247803,0.0006720846,0.0004698478,0.0002764086,0.00380156,0.001249391,0.0002000943,0.002066068],"genre_scores_gemma":[0.9878462,0.002887747,0.001258895,0.001035443,0.000340994,0.003423066,0.001069581,0.00002891033,0.002109087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006813431,"threshold_uncertainty_score":0.02279323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01265715312407783,"score_gpt":0.2903466371104781,"score_spread":0.2776894839864003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}