{"id":"W4379519546","doi":"10.3390/cancers15113064","title":"Irinotecan- vs. Oxaliplatin-Based Doublets in KRASG12C-Mutated Metastatic Colorectal Cancer—A Multicentre Propensity-Score-Matched Retrospective Analysis","year":2023,"lang":"en","type":"article","venue":"Cancers","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Moderna; Calithera Biosciences; Nordic Pharma Group; Les Laboratories Pierre Fabre; Servier; Amgen; Pfizer; McGill University","keywords":"Irinotecan; Medicine; Oxaliplatin; Bevacizumab; FOLFIRI; Oncology; Internal medicine; FOLFOX; Colorectal cancer; Chemotherapy; Retrospective cohort study; Progression-free survival; Cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001853747,0.0003472986,0.0007634385,0.0006766313,0.0002868401,0.0005642776,0.0004645535,0.0004444676,0.001357106],"category_scores_gemma":[0.002692568,0.0003528794,0.001778678,0.001045784,0.0002948846,0.0003181806,0.000402973,0.0003454776,0.000246649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006874311,"about_ca_system_score_gemma":0.0003736116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001173531,"about_ca_topic_score_gemma":0.001321222,"domain_scores_codex":[0.9984661,0.0004957572,0.0002342336,0.0004934958,0.000185376,0.0001250462],"domain_scores_gemma":[0.9978132,0.0004089334,0.001123977,0.0003311147,0.0001331567,0.0001896173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04078365,0.0003885915,0.9408048,0.0002246296,0.005113693,0.0003784929,0.0001098164,0.0008407409,0.002377033,0.0001018964,0.0004015162,0.008475245],"study_design_scores_gemma":[0.001348491,0.007472472,0.9830505,0.00002650183,0.002903434,0.0007719705,0.0001432088,0.002237014,0.0008305209,0.0001138403,0.001069759,0.00003218554],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984336,0.0008788963,0.0001876832,0.00001447843,0.00001133301,0.00004012733,0.0002998692,0.000002576154,0.0001313845],"genre_scores_gemma":[0.9994771,0.0001010536,0.00007511696,0.00001983522,0.00001303473,0.00002073637,0.0002364795,0.000001841918,0.00005490027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001853747,"threshold_uncertainty_score":0.009803653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04216025169199009,"score_gpt":0.3135786266715793,"score_spread":0.2714183749795891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}