{"id":"W4379521430","doi":"10.1136/annrheumdis-2023-eular.1306","title":"POS0231 SUSTAINED EFFICACY AND SAFETY OF BIMEKIZUMAB IN PATIENTS WITH ACTIVE PSORIATIC ARTHRITIS AND PRIOR INADEQUATE RESPONSE TO TUMOUR NECROSIS FACTOR INHIBITORS: RESULTS FROM THE PHASE 3 BE COMPLETE STUDY AND ITS OPEN-LABEL EXTENSION UP TO 1 YEAR","year":2023,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Western Hospital; University Health Network","funders":"University of Toronto; University of Glasgow; Sorbonne Université; University of Washington; University of Occupational and Environmental Health; University of Rochester; Jikei University School of Medicine; Icahn School of Medicine at Mount Sinai","keywords":"Medicine; Psoriatic arthritis; Tolerability; Psoriasis; Adverse effect; Placebo; Internal medicine; Gastroenterology; Arthritis; Surgery; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001955771,0.0008395492,0.001897353,0.0003133242,0.0003177495,0.001057625,0.0004938212,0.001098627,0.003326691],"category_scores_gemma":[0.001287713,0.0004154207,0.001506863,0.0004056695,0.0006825562,0.001351813,0.000339623,0.002526921,0.001288698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005621111,"about_ca_system_score_gemma":0.0009525251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005044235,"about_ca_topic_score_gemma":0.001092795,"domain_scores_codex":[0.9993104,0.0003259337,0.00004677334,0.00008359238,0.00008878891,0.0001445522],"domain_scores_gemma":[0.9993186,0.0001756877,0.0001713453,0.00006268729,0.00004214289,0.0002295054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7558016,0.01822016,0.01112971,0.0006741995,0.001333107,0.0003864355,0.0002243414,0.001899245,0.03073134,0.0002852185,0.003910625,0.1754041],"study_design_scores_gemma":[0.4864121,0.4440086,0.05624053,0.00007290359,0.0008189558,0.001104417,0.0001281618,0.002639832,0.0039726,0.0004437611,0.004083313,0.00007478292],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994,0.002849333,0.0002535492,0.000369609,0.00009450971,0.0002604584,0.0006983811,0.00007754283,0.001396568],"genre_scores_gemma":[0.9955622,0.0009501844,0.000524048,0.0005919464,0.0001302883,0.000240803,0.001100378,0.00001787661,0.0008823148],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003326691,"threshold_uncertainty_score":0.01112884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05887406107156656,"score_gpt":0.3457934302614037,"score_spread":0.2869193691898372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}