{"id":"W4379522201","doi":"10.1136/annrheumdis-2023-eular.4415","title":"POS0048 LIPOPOLYSACCHARIDE ACTIVATED ENTHESEAL MYELOID CELL INHIBITION WITH UPADACITINIB PARADOXICALLY INCREASES MYELOID PRO-INFLAMMATORY CYTOKINES INCLUDING TNF AND IL-23 BY RESTRAINING AN IL-10 NEGATIVE FEEDBACK-BUT T-CELL TNFΑ AND IL-17 IS STRONGLY BLOCKED","year":2023,"lang":"en","type":"article","venue":"","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Memorial University of Newfoundland","funders":"","keywords":"Medicine; Proinflammatory cytokine; Myeloid; Immunology; Tumor necrosis factor alpha; Pharmacology; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001435188,0.0004418772,0.0005566273,0.000198184,0.0001821022,0.0003635545,0.0002950435,0.0004054402,0.008165712],"category_scores_gemma":[0.00009550111,0.0001197284,0.0004384069,0.0002021547,0.000310649,0.0002172169,0.0001443767,0.001536474,0.001726054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000230499,"about_ca_system_score_gemma":0.000557449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009063248,"about_ca_topic_score_gemma":0.001487692,"domain_scores_codex":[0.9997998,0.00002500827,0.00002522069,0.00003404341,0.00004935547,0.00006655719],"domain_scores_gemma":[0.9999235,0.00001011222,0.00001448259,0.00001147555,0.00001108257,0.00002948138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004114855,0.0006539632,0.0003408853,0.0002475005,0.00002723702,0.0002110967,0.00002442002,0.0001687627,0.9850116,0.0002266415,0.002141887,0.006831159],"study_design_scores_gemma":[0.0006477316,0.005728551,0.005692371,0.00002186283,0.00005871299,0.0007113086,0.00007918997,0.001092225,0.9731472,0.0001152662,0.01269033,0.00001533923],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9794748,0.003365618,0.002498304,0.0008959695,0.0007215436,0.0002247679,0.005237083,0.0004417611,0.007140115],"genre_scores_gemma":[0.9792438,0.001884145,0.002747318,0.0003996566,0.0001138166,0.0003463605,0.005326697,0.00004113165,0.009897185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008165712,"threshold_uncertainty_score":0.02731705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02169264341247219,"score_gpt":0.2619673290272325,"score_spread":0.2402746856147603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}