{"id":"W4379522745","doi":"10.1136/annrheumdis-2023-eular.3275","title":"POS0104 A PHASE 2B DOUBLE-BLIND PLACEBO-CONTROLLED RANDOMIZED CLINICAL TRIAL OF SB-061, AN AGGRECAN MIMETIC, IN SUBJECTS WITH SYMPTOMATIC KNEE OSTEOARTHRITIS","year":2023,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Arthritis Society; Dutch Arthritis Society","keywords":"Medicine; Osteoarthritis; Aggrecan; Chondroitin sulfate; Placebo; Hyaluronic acid; Synovial fluid; Internal medicine; Tolerability; ADAMTS; Gastroenterology; Surgery; Pathology; Thrombospondin; Adverse effect; Matrix metalloproteinase; Articular cartilage; Metalloproteinase; Glycosaminoglycan","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001698721,0.002253164,0.003062099,0.0006648293,0.0005632868,0.001156672,0.001238656,0.002608476,0.01668199],"category_scores_gemma":[0.001457892,0.001004675,0.001523836,0.0004640042,0.001475977,0.00122703,0.0004341458,0.003344681,0.002602726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000636637,"about_ca_system_score_gemma":0.001488175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001249027,"about_ca_topic_score_gemma":0.002751763,"domain_scores_codex":[0.9995466,0.0002205442,0.00002852301,0.00008762075,0.00003223904,0.00008444498],"domain_scores_gemma":[0.9994765,0.0001342383,0.00009166454,0.00004029301,0.00004514351,0.0002122362],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9766886,0.007198703,0.0002293867,0.0005994793,0.0004434878,0.00003140741,0.00002430905,0.0001661759,0.004095975,0.0001425131,0.001177911,0.009202085],"study_design_scores_gemma":[0.9624994,0.03602454,0.0005183848,0.00001465322,0.0001192628,0.00001290562,0.00001369083,0.0001272912,0.0002153123,0.00007027465,0.000375403,0.000008809302],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9673769,0.005724859,0.00177371,0.001711276,0.001803184,0.008883085,0.004746602,0.0007164538,0.007263942],"genre_scores_gemma":[0.9509471,0.005080166,0.004204886,0.004470551,0.001084608,0.01210732,0.00594375,0.0001148824,0.01604673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01668199,"threshold_uncertainty_score":0.05580688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06773160299057998,"score_gpt":0.3797958392652434,"score_spread":0.3120642362746634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}