{"id":"W4379534383","doi":"10.1136/annrheumdis-2023-eular.2985","title":"POS0227 SERUM EXTRACELLULAR MATRIX BIOMARKERS IDENTIFY RESPONSE TO GUSELKUMAB IN PSORIATIC ARTHRITIS: POST-HOC ANALYSIS FROM A PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY THROUGH 2 YEARS","year":2023,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Griffith University; University of Leeds; University of Oxford; Janssen Scientific Affairs; Celgene; McGill University; Gilead Sciences; Brigham and Women's Hospital; Amgen; Pfizer; Eli Lilly and Company","keywords":"Medicine; Psoriatic arthritis; Double blind; Post-hoc analysis; Placebo; Arthritis; Internal medicine; Dermatology; Pathology; Alternative medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003833951,0.002047055,0.005297968,0.000543681,0.0006183064,0.001349614,0.0009499571,0.001746073,0.005310593],"category_scores_gemma":[0.0023242,0.0008449937,0.004261503,0.000666879,0.001424021,0.00178233,0.0005996176,0.003224455,0.001038162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006488535,"about_ca_system_score_gemma":0.001190633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006505725,"about_ca_topic_score_gemma":0.001185941,"domain_scores_codex":[0.9979886,0.00102441,0.0001422447,0.000335784,0.0001697611,0.000339137],"domain_scores_gemma":[0.998086,0.0006104449,0.0003811586,0.0002740994,0.0002107241,0.000437605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.9863332,0.003229246,0.0008711284,0.000146402,0.00121351,0.0000151513,0.00001633552,0.0001781522,0.002945289,0.00001573253,0.0001689701,0.004866845],"study_design_scores_gemma":[0.6300372,0.3398032,0.02338199,0.00003035561,0.003266816,0.00004326978,0.00005497703,0.0006034148,0.001982976,0.0001341481,0.0006142991,0.00004725051],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941939,0.002270985,0.0005330874,0.0001963615,0.0002425713,0.0009313071,0.0008538445,0.00008144717,0.0006964816],"genre_scores_gemma":[0.9940949,0.0009398181,0.0006808426,0.0004123466,0.0002661592,0.001161679,0.001049586,0.00003109451,0.001363686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005310593,"threshold_uncertainty_score":0.02027613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03736903366541654,"score_gpt":0.3442062126085569,"score_spread":0.3068371789431404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}