{"id":"W4379537094","doi":"10.3389/fimmu.2023.1209588","title":"Nuanced role for dendritic cell intrinsic IRE1 RNase in the regulation of antitumor adaptive immunity","year":2023,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Comisión Nacional de Investigación Científica y Tecnológica; Bijzonder Onderzoeksfonds UGent; European Research Council; University of California, San Francisco; Leids Universitair Medisch Centrum; Stichting Tegen Kanker; Fonds Wetenschappelijk Onderzoek; Universidad de Chile; Sunnybrook Research Institute; Agencia Nacional de Investigación y Desarrollo; Fondo Nacional de Desarrollo Científico y Tecnológico; Howard Hughes Medical Institute","keywords":"Biology; Dendritic cell; Cancer research; XBP1; Cancer immunotherapy; Oncolytic virus; Immune system; Melanoma; Immunotherapy; Cell biology; Immunology; RNA; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002707423,0.000351516,0.0002646725,0.0001960675,0.0001297651,0.0004383171,0.0001908947,0.0003132134,0.0009267423],"category_scores_gemma":[0.00009868026,0.00009950432,0.0001659153,0.00008711684,0.00035608,0.000460305,0.0002664761,0.0006195177,0.0002756996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002896879,"about_ca_system_score_gemma":0.0001834839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005044353,"about_ca_topic_score_gemma":0.000072317,"domain_scores_codex":[0.9998974,0.00001860777,0.000007347254,0.00003467026,0.00001857129,0.00002332438],"domain_scores_gemma":[0.9999003,0.00001472655,0.00002643541,0.00001445775,0.00001363025,0.00003046727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001702098,0.00001533077,0.0003598761,0.00007677299,0.000002814983,0.0001104064,0.00002066033,0.0001624664,0.9949273,0.001005215,0.00004425383,0.003104645],"study_design_scores_gemma":[0.00005484555,0.0007951909,0.01990241,0.00005015833,0.00002775707,0.00160513,0.0001711735,0.002736834,0.9514441,0.002939335,0.02025282,0.00002010103],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9371963,0.03483671,0.01929506,0.0009613403,0.0001127234,0.00006242584,0.000369139,0.0002196556,0.006946674],"genre_scores_gemma":[0.9881406,0.005103729,0.004047033,0.00009670063,0.00004883716,0.00001957456,0.0001318621,0.00001293213,0.002398707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009267423,"threshold_uncertainty_score":0.003100216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007200715348830385,"score_gpt":0.2269664463366745,"score_spread":0.2197657309878441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}