{"id":"W4379538009","doi":"10.1186/s13287-023-03382-9","title":"Suspension culture improves iPSC expansion and pluripotency phenotype","year":2023,"lang":"en","type":"article","venue":"Stem Cell Research & Therapy","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Alberta","funders":"Breakthrough T1D Canada; Canadian Institutes of Health Research; Juvenile Diabetes Research Foundation Canada; Canada Research Chairs; Stem Cell Network; Diabetes Canada","keywords":"Induced pluripotent stem cell; SOX2; Homeobox protein NANOG; Germ layer; KLF4; Cell biology; Biology; Regenerative medicine; Cell culture; Molecular biology; Stem cell; Genetics; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004776913,0.0004990895,0.0004523995,0.0005193299,0.0002245463,0.001124052,0.0003471435,0.0005902143,0.003121845],"category_scores_gemma":[0.0003814768,0.0002206249,0.0005351235,0.0003179941,0.0002096041,0.0003240559,0.0006442088,0.000720644,0.001527315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003814273,"about_ca_system_score_gemma":0.0003644106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001353009,"about_ca_topic_score_gemma":0.001555644,"domain_scores_codex":[0.9994622,0.00004793377,0.0000888101,0.000115284,0.0002262928,0.00005958364],"domain_scores_gemma":[0.9995073,0.0001468943,0.00009633796,0.00006921918,0.00013363,0.00004646393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005643685,0.00005804046,0.0008041814,0.00006222723,0.00001201895,0.00006745832,0.00003127506,0.0002991015,0.9910732,0.0001172107,0.0002665325,0.007152302],"study_design_scores_gemma":[0.00002068782,0.0004539245,0.01401521,0.00003730818,0.0001087337,0.0004404545,0.00008200949,0.003702738,0.9702197,0.0001498964,0.01075291,0.00001629412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9264225,0.005872237,0.05054642,0.0003228648,0.0002646809,0.0001818131,0.00194537,0.0009311404,0.01351284],"genre_scores_gemma":[0.9693359,0.002000142,0.015351,0.0002171572,0.00006843975,0.0001592915,0.004261639,0.0002229696,0.008383535],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003121845,"threshold_uncertainty_score":0.01044363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04095123777971664,"score_gpt":0.3273255370578481,"score_spread":0.2863742992781314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}