{"id":"W4379598707","doi":"10.1093/brain/awad193","title":"Clinical considerations in early-onset cerebral amyloid angiopathy","year":2023,"lang":"en","type":"review","venue":"Brain","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"UCLH Biomedical Research Centre; Medical Research Council; UK Dementia Research Institute; Research Trainees Coordinating Centre; Alzheimer’s Research UK; University College London Hospitals NHS Foundation Trust; Stroke Association; Rosetrees Trust; University of London; British Heart Foundation; University College London; National Institute for Health and Care Research; Weston Brain Institute; Alzheimer's Research Trust; Alzheimer's Society; Brain Research UK; Center for Outcomes Research and Evaluation, Yale School of Medicine","keywords":"Cerebral amyloid angiopathy; Medicine; Angiopathy; Amyloid (mycology); Neuroscience; Psychology; Pathology; Dementia; Disease; Endocrinology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005887912,0.0005166195,0.001368019,0.0002090052,0.00008119534,0.00006444436,0.0002919736,0.0008170327,0.00006414371],"category_scores_gemma":[0.001445025,0.0004681837,0.0009468272,0.0002783443,0.0001527724,0.000004627868,0.0002912482,0.0003647311,0.0005693749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006153924,"about_ca_system_score_gemma":0.0005092774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008512532,"about_ca_topic_score_gemma":0.000605455,"domain_scores_codex":[0.9966947,0.0006579295,0.001103882,0.0009042631,0.0001640987,0.0004751696],"domain_scores_gemma":[0.9979943,0.0006433045,0.0003370247,0.0008189532,0.00003995179,0.0001664597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003713557,0.001128991,0.2078024,0.004054024,0.002289701,0.0007164931,0.0001335995,0.000006252895,0.000008540383,0.0004634911,0.3553946,0.4279647],"study_design_scores_gemma":[0.0007623351,0.0002069691,0.01121001,0.001442194,0.0002680523,0.00006088884,0.00001782831,0.000001050197,0.00000994599,0.0001262353,0.9852969,0.0005975831],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00418628,0.9929106,0.00001377568,0.0004530727,0.0004781019,0.001107424,0.0005065653,0.00007107877,0.0002730823],"genre_scores_gemma":[0.002170857,0.9921564,0.0002451801,0.0007933867,0.0004932585,0.0005893556,0.001187715,0.0001413546,0.002222473],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6299022,"threshold_uncertainty_score":0.999777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0804874205354619,"score_gpt":0.3976345495074805,"score_spread":0.3171471289720186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}