{"id":"W4379600114","doi":"10.17879/freeneuropathology-2022-3684","title":"Medulloblastoma and Cowden Syndrome: Further Evidence of an Association","year":2021,"lang":"en","type":"article","venue":"PubMed","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill Genome Centre; McGill University Health Centre; Jewish General Hospital; Montreal Children's Hospital; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Cowden syndrome; Medulloblastoma; PTEN; Germline; Medicine; Sonic hedgehog; Pathology; Germline mutation; Cancer research; Hamartoma; PTCH1; Internal medicine; Oncology; Biology; Mutation; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001663975,0.0003542158,0.0002030233,0.001432279,0.0004701981,0.0003177168,0.000252068,0.0005124781,0.005205833],"category_scores_gemma":[0.001065066,0.000180953,0.0002242752,0.0008513478,0.0003340075,0.0002279574,0.0004061675,0.0003250228,0.000305321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002419794,"about_ca_system_score_gemma":0.0004149145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003813921,"about_ca_topic_score_gemma":0.004627047,"domain_scores_codex":[0.9998019,0.00003252313,0.00002448517,0.0000500802,0.00005747443,0.00003361539],"domain_scores_gemma":[0.9992319,0.0002246979,0.0002721509,0.0000561568,0.00006432136,0.0001507299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006642009,0.00007098139,0.9210677,0.0001456972,0.0002082558,0.03776854,0.0004911887,0.0001462066,0.0233268,0.0008869387,0.000735742,0.01448784],"study_design_scores_gemma":[0.00002600087,0.0001487304,0.8789928,0.0000464111,0.0001389006,0.1114838,0.0003034903,0.0004453828,0.00331754,0.0003213652,0.004762096,0.00001359121],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941031,0.002102966,0.0002618738,0.0001740281,0.00002435076,0.00000706431,0.0002509727,0.0000223927,0.003053142],"genre_scores_gemma":[0.9979803,0.0008133063,0.0002699904,0.00002707946,0.00002890891,0.00000377469,0.000147155,0.000004141099,0.0007255109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005205833,"threshold_uncertainty_score":0.01741529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01461534655176357,"score_gpt":0.2417946998439021,"score_spread":0.2271793532921385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}