{"id":"W4379600446","doi":"10.1021/acsinfecdis.3c00167","title":"Nutrient Limitation Sensitizes <i>Pseudomonas aeruginosa</i> to Vancomycin","year":2023,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Pseudomonas aeruginosa; Microbiology; Antibiotics; Peptidoglycan; Vancomycin; Bacteria; Mutant; Biology; Siderophore; Glycopeptide; Antibiotic resistance; Biochemistry; Genetics; Staphylococcus aureus; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000597166,0.0001628425,0.0001368819,0.0001210226,0.0001175564,0.00003924003,0.000122124,0.0001605914,0.00000723838],"category_scores_gemma":[0.0001699963,0.0001623235,0.00008001164,0.0003609497,0.00005601846,0.000002901204,0.0001935705,0.00005716034,0.0002629997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000166876,"about_ca_system_score_gemma":0.00004895232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001458494,"about_ca_topic_score_gemma":0.00004934195,"domain_scores_codex":[0.9990174,0.00004037721,0.0001623274,0.0003723596,0.0001079942,0.0002995918],"domain_scores_gemma":[0.9993559,0.00002113375,0.00004839395,0.0003425103,0.00009533356,0.0001367131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005867386,0.0001055347,0.008209826,0.00001708981,0.00005095389,0.00001349545,0.0000257225,0.0001670645,0.9574479,0.0004433553,0.02904474,0.00441564],"study_design_scores_gemma":[0.001036103,0.0008107425,0.046456,0.00002202719,0.00006738584,0.00003104149,0.00009862806,0.00002033059,0.741893,0.001828379,0.2071923,0.0005440926],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975038,0.0001629303,0.0002486065,0.0006144376,0.000473938,0.0002626581,0.00008281328,0.0002023822,0.0004484051],"genre_scores_gemma":[0.9973917,0.000458866,0.00007378501,0.0008597921,0.0004025402,0.00006246025,0.0003873282,0.00002739018,0.0003361191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2155549,"threshold_uncertainty_score":0.661936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007364540396658742,"score_gpt":0.2356959750705801,"score_spread":0.2283314346739214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}