{"id":"W4379645119","doi":"10.1136/jitc-2023-006802","title":"Early decrease of blood myeloid-derived suppressor cells during checkpoint inhibition is a favorable biomarker in metastatic melanoma","year":2023,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences North","funders":"Medizinischen Fakultät, Eberhard Karls Universität Tübingen; Klaus Tschira Stiftung; Eberhard Karls Universität Tübingen; Merck Sharp and Dohme; Bristol-Myers Squibb","keywords":"Medicine; Melanoma; Biomarker; Oncology; Myeloid-derived Suppressor Cell; Immune checkpoint; Immune system; Flow cytometry; Myeloid; Internal medicine; Cancer; Immunotherapy; Cohort; Immunology; Cancer research; Suppressor; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004102288,0.0002156647,0.0002941049,0.0005053754,0.0001872303,0.0003782322,0.0001635038,0.0002930173,0.0008380992],"category_scores_gemma":[0.001130123,0.0001108028,0.0001114782,0.0003496432,0.0001949705,0.0002110699,0.0002030772,0.0004465432,0.0002077384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002024635,"about_ca_system_score_gemma":0.0001857588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003277121,"about_ca_topic_score_gemma":0.0004375755,"domain_scores_codex":[0.9998558,0.00003180698,0.00001633437,0.00003967278,0.00003449722,0.00002195283],"domain_scores_gemma":[0.99928,0.0001694604,0.0003066385,0.00004466508,0.0000818167,0.0001173858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001158151,0.00006845263,0.9567565,0.00004198616,0.00002769725,0.0001295521,0.0000652048,0.0002514858,0.03117735,0.00002968017,0.0001400588,0.01015377],"study_design_scores_gemma":[0.00001153382,0.0005091947,0.9932227,0.000007052906,0.00003050709,0.0006657782,0.00005189807,0.0006415537,0.004445711,0.00004154817,0.00036878,0.000003711173],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988173,0.0004810166,0.0002587253,0.00002378819,0.000004405025,0.00001127651,0.0001180568,0.00001328664,0.0002722108],"genre_scores_gemma":[0.9994287,0.00008553686,0.0002123113,0.00001312909,0.0000105501,0.000008409825,0.0001524964,0.000002101348,0.00008678715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008380992,"threshold_uncertainty_score":0.002803743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01955512069351003,"score_gpt":0.2874628456149711,"score_spread":0.2679077249214611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}