{"id":"W4379646019","doi":"10.1200/jco.2023.41.17_suppl.lba9016","title":"Intracranial efficacy of sotorasib versus docetaxel in pretreated<i> KRAS</i> G12C-mutated advanced non-small cell lung cancer (NSCLC): Practice-informing data from a global, phase 3, randomized, controlled trial (RCT).","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Amgen","keywords":"Medicine; Docetaxel; Oncology; KRAS; Internal medicine; Randomized controlled trial; Lung cancer; Brain metastasis; Cancer; Chemotherapy; Metastasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001051452,0.0008140524,0.001361699,0.0002930069,0.000195401,0.0007167803,0.0005169802,0.0008265328,0.003229702],"category_scores_gemma":[0.001551506,0.0003461529,0.001302415,0.0003900035,0.0005966236,0.0005929272,0.0002797332,0.001964215,0.0004291113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000924607,"about_ca_system_score_gemma":0.0009834265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001400531,"about_ca_topic_score_gemma":0.004778076,"domain_scores_codex":[0.9994721,0.0003078555,0.00004944461,0.00006965152,0.0000475844,0.0000533916],"domain_scores_gemma":[0.9990145,0.0002477219,0.0004093779,0.00005808994,0.00006045619,0.0002098195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9340895,0.006055841,0.001266716,0.001841235,0.001620022,0.00004594486,0.00008626845,0.0007733862,0.005557809,0.0001139279,0.001047872,0.04750135],"study_design_scores_gemma":[0.7157926,0.2699764,0.007012476,0.0001714825,0.002532479,0.00009230011,0.00005645346,0.0007268253,0.001634252,0.0001893472,0.001787712,0.00002765459],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855657,0.006910587,0.0003751487,0.0005189048,0.0002356851,0.002294132,0.0008432128,0.00007911949,0.003177477],"genre_scores_gemma":[0.993605,0.002670455,0.0006181447,0.0004152539,0.0001314411,0.001055244,0.0006078478,0.00001217803,0.0008844964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003229702,"threshold_uncertainty_score":0.01080447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08553337113873839,"score_gpt":0.5350344985612282,"score_spread":0.4495011274224898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}