{"id":"W4379648747","doi":"10.3389/fmicb.2023.1065609","title":"Development of virus-like particles with inbuilt immunostimulatory properties as vaccine candidates","year":2023,"lang":"en","type":"article","venue":"Frontiers in Microbiology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Health and Medical Research Council; Sanofi Pasteur; Department of Education and Training; Ontario Ministry of Natural Resources and Forestry; Australian Government; Australian National Fabrication Facility; RMIT University; Medical Research Council; Sanofi","keywords":"Virology; Immunogenicity; Dengue virus; Adjuvant; Virus-like particle; Dengue vaccine; Biology; Virus; Dengue fever; Antibody; Immunity; Immune system; Microbiology; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003123831,0.0003165833,0.0003032728,0.0002421841,0.000108064,0.0004107444,0.0002311405,0.000434658,0.0005636487],"category_scores_gemma":[0.0002750713,0.0001920714,0.0003034264,0.0001393039,0.0001849451,0.0003558958,0.0002030667,0.0005198999,0.0003963479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000249819,"about_ca_system_score_gemma":0.0001645032,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001331922,"about_ca_topic_score_gemma":0.0001655,"domain_scores_codex":[0.9998883,0.00002784268,0.00001081767,0.00002013105,0.00003257841,0.00002029651],"domain_scores_gemma":[0.9999059,0.00001824625,0.00002185452,0.00001127533,0.00002115447,0.00002157788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006922399,0.00006001525,0.0001763921,0.00008624593,0.000008143447,0.00007945998,0.0000216101,0.0007924223,0.9912874,0.0004302429,0.00006057052,0.006928297],"study_design_scores_gemma":[0.00004639182,0.001623823,0.001120618,0.00002347503,0.00003034432,0.0003387568,0.00002801308,0.002716649,0.9832838,0.0002684114,0.01050857,0.00001123416],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.939923,0.007704349,0.04800606,0.0003324293,0.0001545251,0.0004170695,0.0003829368,0.0001579807,0.002921609],"genre_scores_gemma":[0.9444665,0.003921791,0.04700318,0.0001867242,0.00004788295,0.0002017486,0.0009482502,0.00003928502,0.003184669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005636487,"threshold_uncertainty_score":0.001885593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02299777472425734,"score_gpt":0.2850957034979101,"score_spread":0.2620979287736527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}