{"id":"W4379649641","doi":"10.1136/annrheumdis-2023-eular.2523","title":"POS1522 CHANGES IN SERUM CYTOKINES BY WEEK 24 CORRELATE WITH LONG-TERM EFFICACY OF GUSELKUMAB THROUGH 2-YEARS IN BIO-NAÏVE ADULTS WITH PSA","year":2023,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Memorial University of Newfoundland","funders":"Sun Pharma; Genentech; Celgene; Gilead Sciences; Amgen; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Psoriatic arthritis; Internal medicine; Psoriasis; Psoriasis Area and Severity Index; Immunology; Biomarker; Arthritis; Cytokine; Gastroenterology; C-reactive protein; Placebo; Inflammation; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004624041,0.0003025084,0.0004847484,0.0003052229,0.000230253,0.000604256,0.0001703499,0.0004670651,0.001642723],"category_scores_gemma":[0.00136918,0.0001748543,0.0005240886,0.00033533,0.0001772008,0.0005617507,0.0002390275,0.0007163099,0.0004158205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002277962,"about_ca_system_score_gemma":0.0002187418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006012935,"about_ca_topic_score_gemma":0.0009300046,"domain_scores_codex":[0.9996785,0.00006686332,0.00004115619,0.0000637532,0.00006601121,0.00008375278],"domain_scores_gemma":[0.9990394,0.0001874557,0.0004437805,0.00004849733,0.00009001944,0.0001908857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007781823,0.0004802625,0.9606915,0.00006474452,0.0002573877,0.0003189245,0.0001230734,0.0002512652,0.006393416,0.00003855398,0.0002930738,0.02330605],"study_design_scores_gemma":[0.00005147681,0.002142061,0.996262,0.00001068355,0.00009938714,0.0002991185,0.00008029793,0.0002272637,0.000430366,0.0000303889,0.0003594334,0.000007553281],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979893,0.0009467,0.00007641201,0.00006087241,0.0000194616,0.00001547159,0.0002174833,0.000009411461,0.0006649661],"genre_scores_gemma":[0.9990842,0.000156064,0.00005932997,0.00004708442,0.00002118164,0.00001049438,0.0002314301,0.000001631242,0.0003885517],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001642723,"threshold_uncertainty_score":0.005495489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02736304913072324,"score_gpt":0.2609734945891015,"score_spread":0.2336104454583782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}