{"id":"W4379650502","doi":"10.1136/annrheumdis-2023-eular.1709","title":"AB1086 COVID-19–RELATED ADVERSE EVENTS IN THE PHASE 3 POETYK TRIALS OF THE ALLOSTERIC TYROSINE KINASE 2 INHIBITOR, DEUCRAVACITINIB, IN PATIENTS WITH MODERATE TO SEVERE PLAQUE PSORIASIS","year":2023,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Probity Medical Research; Queen's University","funders":"Janssen Research and Development; Universidade Federal de Uberlândia; McGill University; Bristol-Myers Squibb; University of Washington; Monash University","keywords":"Medicine; Adverse effect; Psoriasis; Allosteric regulation; Plaque psoriasis; Coronavirus disease 2019 (COVID-19); Tyrosine kinase; Dermatology; Virology; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001591934,0.0004773476,0.001068372,0.0001745815,0.0003048361,0.0007014163,0.0003358022,0.0005484178,0.002165485],"category_scores_gemma":[0.0009115053,0.0002045718,0.001052153,0.0002115007,0.0002943798,0.0004477935,0.0001749856,0.002056779,0.0003508384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006310588,"about_ca_system_score_gemma":0.0005183084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006289896,"about_ca_topic_score_gemma":0.002917729,"domain_scores_codex":[0.9994429,0.0003052807,0.00003750456,0.00005471169,0.00008175827,0.000077853],"domain_scores_gemma":[0.9995149,0.000172489,0.0001099764,0.00002494606,0.00003553884,0.0001421497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.489242,0.007617204,0.03145987,0.002689118,0.004481892,0.0007973847,0.000320632,0.003796971,0.03661579,0.0007789965,0.01520316,0.406997],"study_design_scores_gemma":[0.3922244,0.3358738,0.2059902,0.0005179739,0.004325455,0.004304567,0.0003457341,0.007621911,0.01236062,0.001594375,0.03466355,0.0001775191],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.97974,0.01386742,0.0003129485,0.0008231292,0.0002162322,0.0003062342,0.0007345487,0.00006993749,0.003929661],"genre_scores_gemma":[0.9942505,0.002836601,0.0003280875,0.0005292076,0.0001063423,0.0001329718,0.0007067676,0.0000107742,0.001098774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002165485,"threshold_uncertainty_score":0.008419037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05191540164228455,"score_gpt":0.3139613809978373,"score_spread":0.2620459793555527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}