{"id":"W4379654635","doi":"10.1016/j.jhep.2023.05.023","title":"Evaluation of RNAi therapeutics VIR-2218 and ALN-HBV for chronic hepatitis B: Results from randomized clinical trials","year":2023,"lang":"en","type":"article","venue":"Journal of Hepatology","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":100,"is_retracted":false,"has_abstract":false,"ca_institutions":"Richmond Hospital","funders":"Vir Biotechnology; Alnylam Pharmaceuticals","keywords":"Medicine; Chronic hepatitis; Randomized controlled trial; Virology; Internal medicine; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006645591,0.001705048,0.004921317,0.0005824582,0.0004542657,0.001623782,0.0008631147,0.002316355,0.005043335],"category_scores_gemma":[0.005749028,0.000573633,0.005270386,0.0006848224,0.001703682,0.001515492,0.0004348735,0.003143814,0.0006998655],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001141983,"about_ca_system_score_gemma":0.001035222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001043319,"about_ca_topic_score_gemma":0.001897642,"domain_scores_codex":[0.9974205,0.00168039,0.0002586756,0.0002400614,0.0002091994,0.0001910839],"domain_scores_gemma":[0.9967642,0.001768519,0.0007897104,0.0002007843,0.0002074148,0.0002693414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.873484,0.003557695,0.001083292,0.01012396,0.01657633,0.00007511239,0.0001011033,0.0007171356,0.004042233,0.0004360791,0.001595231,0.08820791],"study_design_scores_gemma":[0.8913931,0.08513727,0.003662367,0.001061873,0.01296762,0.00008733785,0.00009213998,0.0004880694,0.001163999,0.0006630543,0.003230986,0.00005225482],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7330762,0.2422548,0.003806211,0.004890498,0.002212371,0.004979724,0.001852787,0.0003229197,0.00660466],"genre_scores_gemma":[0.9289176,0.05512927,0.004012878,0.003351507,0.000833206,0.003151802,0.001408343,0.0000585001,0.003137078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006645591,"threshold_uncertainty_score":0.03514564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3254271566670642,"score_gpt":0.5110320537125496,"score_spread":0.1856048970454854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}