{"id":"W4379660641","doi":"10.2139/ssrn.4470109","title":"Early Life Stress Aggravates Disease Pathogenesis in Mice with Experimental Autoimmune Encephalomyelitis: Support for a Two-Hit Hypothesis of Multiple Sclerosis Etiology","year":2023,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hotchkiss Brain Institute; University of Calgary; University of Lethbridge","funders":"","keywords":"Experimental autoimmune encephalomyelitis; Multiple sclerosis; Etiology; Pathogenesis; Disease; Encephalomyelitis; Medicine; Immunology; Autoimmune disease; Neuroscience; Psychology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002718224,0.0007748707,0.0007017148,0.0006415072,0.0001813679,0.0004075257,0.000208182,0.0005292236,0.001893961],"category_scores_gemma":[0.0002462885,0.0001661945,0.0005069576,0.0002562599,0.0003640453,0.0002938434,0.00041781,0.001259794,0.0003023732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001849377,"about_ca_system_score_gemma":0.0001638395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001663085,"about_ca_topic_score_gemma":0.0003177683,"domain_scores_codex":[0.9997379,0.00006208708,0.00002155369,0.00005387135,0.00005090213,0.00007362554],"domain_scores_gemma":[0.9994279,0.00005462256,0.0002207044,0.00008123623,0.00003446112,0.0001811494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001382146,0.0001826262,0.002266037,0.0000902013,0.00004025854,0.0003358955,0.00006359953,0.00004379669,0.9929482,0.0001498067,0.00008840866,0.002409035],"study_design_scores_gemma":[0.0002608556,0.007154059,0.3009256,0.00009151681,0.0002851752,0.003214289,0.0005802889,0.001233625,0.680928,0.002177911,0.003067009,0.00008166289],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954618,0.001518101,0.00143194,0.0003038647,0.0001014131,0.00001653161,0.0003530155,0.00008356813,0.0007297229],"genre_scores_gemma":[0.9948363,0.00154446,0.001272355,0.000167438,0.00007108308,0.00004076011,0.0003432668,0.00003065905,0.001693707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001893961,"threshold_uncertainty_score":0.006335974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04733845554883458,"score_gpt":0.3005550252646707,"score_spread":0.2532165697158361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}