{"id":"W4379662208","doi":"10.1200/jco.2023.41.17_suppl.lba5507","title":"Phase III MIRASOL (GOG 3045/ENGOT-ov55) study: Initial report of mirvetuximab soravtansine vs. investigator's choice of chemotherapy in platinum-resistant, advanced high-grade epithelial ovarian, primary peritoneal, or fallopian tube cancers with high folate receptor-alpha expression.","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital; McGill University Health Centre; Royal Victoria Regional Health Centre","funders":"ImmunoGen","keywords":"Medicine; Clinical endpoint; Tolerability; Internal medicine; Progression-free survival; Oncology; Fallopian tube; Chemotherapy; Ovarian cancer; Topotecan; Paclitaxel; Nausea; Randomized controlled trial; Urology; Surgery; Cancer; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002992005,0.000541297,0.00442485,0.0005156022,0.00008704724,0.00001183283,0.0004951949,0.0005935038,0.0002445698],"category_scores_gemma":[0.003273331,0.0003870204,0.0003654183,0.001148319,0.0009873849,0.0004332041,0.0001120258,0.001703192,0.000002203975],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007334177,"about_ca_system_score_gemma":0.007889159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007593569,"about_ca_topic_score_gemma":0.0007078878,"domain_scores_codex":[0.990888,0.0008020604,0.005691882,0.000706457,0.001260564,0.0006510491],"domain_scores_gemma":[0.9894425,0.002587622,0.005572507,0.0007139587,0.0009420181,0.0007413705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4488926,0.01565534,0.02625801,0.0005502976,0.002812416,0.01115031,0.00309298,0.0007184833,0.3710272,0.00005489649,0.001938089,0.1178494],"study_design_scores_gemma":[0.4491597,0.1552075,0.2704618,0.003712829,0.001103758,0.001211523,0.002628645,0.00009548066,0.0533203,0.0005868135,0.06134952,0.001162137],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910342,0.0002944711,0.0001822222,0.005501023,0.001490528,0.00126105,0.0001050805,0.0000586459,0.00007281413],"genre_scores_gemma":[0.9724776,0.0006077314,0.0235313,0.001351784,0.001552068,0.00006133755,0.00004787898,0.000131254,0.0002391149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3177069,"threshold_uncertainty_score":0.9998581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07782574795674795,"score_gpt":0.4396865665417338,"score_spread":0.3618608185849859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}