{"id":"W4379662208","doi":"10.1200/jco.2023.41.17_suppl.lba5507","title":"Phase III MIRASOL (GOG 3045/ENGOT-ov55) study: Initial report of mirvetuximab soravtansine vs. investigator's choice of chemotherapy in platinum-resistant, advanced high-grade epithelial ovarian, primary peritoneal, or fallopian tube cancers with high folate receptor-alpha expression.","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital; McGill University Health Centre; Royal Victoria Regional Health Centre","funders":"ImmunoGen","keywords":"Medicine; Clinical endpoint; Tolerability; Internal medicine; Progression-free survival; Oncology; Fallopian tube; Chemotherapy; Ovarian cancer; Topotecan; Paclitaxel; Nausea; Randomized controlled trial; Urology; Surgery; Cancer; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002995024,0.002157653,0.002208339,0.0005615778,0.00034527,0.001236202,0.001233195,0.001872939,0.005021557],"category_scores_gemma":[0.001513118,0.0006984144,0.00167946,0.0004692133,0.00105208,0.0008089126,0.00041127,0.003193003,0.001395255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001307249,"about_ca_system_score_gemma":0.001654337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002279124,"about_ca_topic_score_gemma":0.004915548,"domain_scores_codex":[0.9991615,0.0005219263,0.00003085349,0.00009108492,0.00006084542,0.0001338449],"domain_scores_gemma":[0.9990765,0.0002548471,0.0001887366,0.0000791416,0.00004548982,0.0003552927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9404274,0.02122006,0.001998537,0.0005078721,0.001020643,0.00008379031,0.0001178999,0.001053481,0.005486795,0.000191354,0.002394596,0.02549767],"study_design_scores_gemma":[0.830032,0.161286,0.004500339,0.00003868608,0.000542637,0.00007681328,0.00003632211,0.0007968423,0.001089759,0.0001758227,0.001403751,0.00002100143],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836876,0.003012454,0.0007930264,0.0007849876,0.000299587,0.004741896,0.002949102,0.0001907162,0.003540518],"genre_scores_gemma":[0.9823569,0.001802492,0.001734962,0.001547865,0.0003011328,0.004036643,0.004024558,0.00006781278,0.004127602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005021557,"threshold_uncertainty_score":0.01679873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07782574795674795,"score_gpt":0.4396865665417338,"score_spread":0.3618608185849859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}