{"id":"W4379741138","doi":"10.1172/jci.insight.169650","title":"CNS-dominant human FMRP isoform rescues seizures, fear, and sleep abnormalities in Fmr1-KO mice","year":2023,"lang":"en","type":"article","venue":"JCI Insight","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"University of Toronto","keywords":"Fragile X syndrome; Neuroscience; Transduction (biophysics); FMR1; Gene isoform; Adeno-associated virus; Viral vector; Biology; Medicine; Vector (molecular biology); Gene; Genetics; Fragile x","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001340409,0.0001824225,0.0001552499,0.0001210941,0.0001540668,0.00004140134,0.0001551628,0.0001281937,0.00001746524],"category_scores_gemma":[0.00002586103,0.0001722649,0.00004677722,0.0001707127,0.000100377,0.000006544144,0.0002489735,0.00009893753,0.0000276596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001212069,"about_ca_system_score_gemma":0.00003334721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001246157,"about_ca_topic_score_gemma":0.0007958971,"domain_scores_codex":[0.9988806,0.00003899954,0.0002367532,0.0003693666,0.0001300668,0.0003442628],"domain_scores_gemma":[0.9996251,0.00001060155,0.00004415255,0.0002165527,0.00002884968,0.00007477594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00008479568,0.00009702855,0.007278478,0.00009026008,0.00004757474,0.00007313223,0.001152276,0.00003763727,0.9778764,0.000464781,0.01065954,0.002138111],"study_design_scores_gemma":[0.001718579,0.0004535106,0.368203,0.00004915778,0.00001899657,0.00003872963,0.0009291488,0.00009879946,0.3241044,0.0006277233,0.3030937,0.0006641946],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914718,0.001559338,0.000004805669,0.0002489187,0.000134505,0.0001729456,0.00001536821,0.00001961581,0.006372702],"genre_scores_gemma":[0.9944094,0.001927847,0.00008298289,0.000373164,0.00003581406,0.00003081932,0.00016447,0.00002985359,0.002945604],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6537719,"threshold_uncertainty_score":0.7024757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01271505740210368,"score_gpt":0.2438788237983321,"score_spread":0.2311637663962284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}