{"id":"W4379741884","doi":"10.1016/j.jtho.2023.05.021","title":"Early Circulating Tumor DNA Dynamics and Efficacy of Lorlatinib in Patients With Treatment-Naive, Advanced, ALK-Positive NSCLC","year":2023,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Universitair Medisch Centrum Groningen; Yuhan; BeiGene; Chugai Pharmaceutical; CMC Microsystems; Amgen; Pfizer; AstraZeneca; Ono Pharmaceutical; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Crizotinib; Medicine; Hazard ratio; Internal medicine; Confidence interval; Biomarker; Oncology; Tyrosine-kinase inhibitor; Progression-free survival; Gastroenterology; Overall survival; Cancer; Lung cancer; Genetics; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007620226,0.0002096507,0.0004090462,0.0002022438,0.0001570288,0.0004309379,0.0001785966,0.0003461549,0.0008437302],"category_scores_gemma":[0.001706552,0.0001233452,0.0003020557,0.0001559117,0.0001597854,0.0003388127,0.0001465992,0.0004486651,0.000143238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004263802,"about_ca_system_score_gemma":0.0002324857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005894888,"about_ca_topic_score_gemma":0.0009649415,"domain_scores_codex":[0.9996769,0.0001242723,0.00002814033,0.00007188162,0.00005798069,0.00004080731],"domain_scores_gemma":[0.9989672,0.0003446168,0.0004502665,0.00003615162,0.00006732033,0.0001345032],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02427132,0.0006384894,0.9071075,0.0001291011,0.0003484694,0.0001674497,0.00009016169,0.001113024,0.01170355,0.0000361157,0.0004664861,0.05392834],"study_design_scores_gemma":[0.0006668461,0.01065617,0.9814562,0.00002449118,0.000265693,0.0006797874,0.00007050082,0.002416741,0.002708213,0.00007490815,0.0009643467,0.00001614367],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986886,0.000836839,0.00007441452,0.00005780621,0.000005854903,0.00001000402,0.0001135393,0.00000836339,0.0002045286],"genre_scores_gemma":[0.9995576,0.00008077011,0.00006628664,0.0000377263,0.000008865926,0.000006647666,0.0001363942,8.583031e-7,0.0001049845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008437302,"threshold_uncertainty_score":0.004029989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007478386264094088,"score_gpt":0.3143189457278874,"score_spread":0.3068405594637933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}