{"id":"W4379742493","doi":"10.1186/s12929-023-00935-1","title":"Akkermansia muciniphila and its membrane protein ameliorates intestinal inflammatory stress and promotes epithelial wound healing via CREBH and miR-143/145","year":2023,"lang":"en","type":"article","venue":"Journal of Biomedical Science","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Northern Ireland Chest Heart and Stroke; Queen's University; Queen's University Belfast; Northern Ireland Chest, Heart and Stroke Association; British Heart Foundation; Department for the Economy; National Institutes of Health; Wayne State University","keywords":"Akkermansia muciniphila; Tight junction; Cell biology; Biology; Downregulation and upregulation; Unfolded protein response; Microbiology; Barrier function; Inflammation; Endoplasmic reticulum; Gut flora; Immunology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001571469,0.0004073506,0.0004087456,0.0003569012,0.0001932974,0.0002561468,0.0002183411,0.0003066492,0.00181315],"category_scores_gemma":[0.0001182296,0.0001257685,0.0003985676,0.0001358743,0.0003249237,0.000277823,0.0002268028,0.0008390425,0.0002402877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001811035,"about_ca_system_score_gemma":0.0002272916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003486052,"about_ca_topic_score_gemma":0.0004687653,"domain_scores_codex":[0.999855,0.00001831397,0.00001275647,0.00002806413,0.00004069289,0.00004510633],"domain_scores_gemma":[0.9998955,0.000007799063,0.00004365945,0.000007843953,0.00001277914,0.00003253155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008739739,0.0001745074,0.0002522013,0.0002059677,0.0000172675,0.0000528814,0.0000289583,0.00004883948,0.9943873,0.00007516988,0.0001137134,0.003769192],"study_design_scores_gemma":[0.000196824,0.003440548,0.01401194,0.00005228699,0.0001431344,0.0004382485,0.0001870679,0.001419667,0.9731751,0.0001514728,0.006764302,0.00001936548],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897069,0.005219087,0.002681762,0.0002875716,0.0001260693,0.00005492799,0.000366431,0.0002126143,0.001344677],"genre_scores_gemma":[0.9934821,0.001866242,0.001880276,0.0001165646,0.00004012365,0.00007920978,0.0003491361,0.00002447744,0.002161847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00181315,"threshold_uncertainty_score":0.006065547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01131328668767929,"score_gpt":0.2774565411789305,"score_spread":0.2661432544912512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}