{"id":"W4379742689","doi":"10.1089/ipm.10.03.04","title":"One and Done? How CRISPR Is Changing the Clinical Outlook for Multiple Diseases","year":2023,"lang":"en","type":"article","venue":"Inside Precision Medicine","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"CARE Canada","funders":"","keywords":"CRISPR; Download; Medicine; Clinical microbiology; Family medicine; Internal medicine; Library science; Gerontology; Computer science; World Wide Web; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005446522,0.000117458,0.0001885227,0.00007175093,0.0001087539,0.00001611435,0.0001301481,0.00009022406,0.000009265445],"category_scores_gemma":[0.001643161,0.00008085491,0.00007197139,0.0001279818,0.0001019373,0.000002752286,0.0001678801,0.00007736713,0.000004592722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003033048,"about_ca_system_score_gemma":0.00001543818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004003103,"about_ca_topic_score_gemma":0.00001299424,"domain_scores_codex":[0.9990726,0.00003567507,0.0001937142,0.0003124352,0.0001583172,0.0002272213],"domain_scores_gemma":[0.9990866,0.0003539149,0.00004552424,0.0003320443,0.0000706482,0.0001112446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000491724,0.00009764546,0.02463594,0.0001933525,0.0002717919,0.0000113058,0.001530502,0.000239805,0.2996752,0.00005716657,0.2884089,0.3843867],"study_design_scores_gemma":[0.00775179,0.001840936,0.1341375,0.0004472188,0.0003511914,0.00002605531,0.002765838,0.01549698,0.1198708,0.001402882,0.7151647,0.0007440699],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8956574,0.006304244,0.07490131,0.02120653,0.0009395114,0.0007628833,0.00005753104,0.00007060806,0.0001000228],"genre_scores_gemma":[0.9938363,0.001821738,0.0006709996,0.001345567,0.001138965,0.00005541545,0.00007322989,0.00002456805,0.001033161],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4267558,"threshold_uncertainty_score":0.3297167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05277204017940281,"score_gpt":0.3914139401871078,"score_spread":0.3386419000077051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}