{"id":"W4379746033","doi":"10.1101/2023.06.07.544021","title":"CDK8 inhibitors antagonize HIV-1 reactivation and promote provirus latency in T cells","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; Simon Fraser University; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Provirus; Small hairpin RNA; Biology; Cyclin-dependent kinase 8; Kinase; Mediator; Transcription (linguistics); RNA interference; Small interfering RNA; Viral replication; Cell biology; Virology; RNA; Virus; Gene; Signal transduction; Genetics; Genome; Notch signaling pathway","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001056933,0.0002711567,0.0001840511,0.0001998324,0.0001254871,0.0002534873,0.0002133073,0.0001452354,0.004889329],"category_scores_gemma":[0.0001091621,0.00008653149,0.0001633316,0.0001011274,0.000123546,0.0001349374,0.0001485808,0.0005431566,0.001047821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001740721,"about_ca_system_score_gemma":0.0001750081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004840331,"about_ca_topic_score_gemma":0.0007532595,"domain_scores_codex":[0.9999354,0.0000107189,0.000005231741,0.000007652096,0.00001540584,0.00002558261],"domain_scores_gemma":[0.9999484,0.0000179544,0.00000706926,0.000007101017,0.000005917142,0.0000136228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009008014,0.0002751147,0.0003200655,0.00009462338,0.00001577747,0.00009027312,0.00001602174,0.0004013893,0.9880961,0.000480648,0.0007898114,0.008519183],"study_design_scores_gemma":[0.00009516974,0.0004875005,0.001585627,0.00000538721,0.000009841017,0.0001361942,0.00001243207,0.0009723337,0.9917092,0.00008728288,0.004896983,0.000002103037],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.975426,0.004399856,0.002933797,0.000299326,0.0001624223,0.00008467021,0.001446282,0.0002927426,0.01495498],"genre_scores_gemma":[0.985635,0.00160577,0.00174396,0.00008461116,0.00003920719,0.0000572859,0.0009123521,0.00004792235,0.009873693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004889329,"threshold_uncertainty_score":0.01635647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0167008206646081,"score_gpt":0.2295694714167173,"score_spread":0.2128686507521092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}