{"id":"W4379768913","doi":"10.1001/jamaoncol.2023.1374","title":"Changes to Primary End Points in Randomized Clinical Trials on Immune Checkpoint Inhibitors in Urothelial, Renal Cell, and Lung Cancers","year":2023,"lang":"en","type":"review","venue":"JAMA Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Medicine; Oncology; Clinical trial; Nivolumab; Immune checkpoint; Internal medicine; Endpoint Determination; Urothelial cancer; Immunotherapy; Cancer; Bladder cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch","metaepi_broad"],"consensus_categories":[],"category_scores_codex":[0.02547155,0.00139431,0.009284206,0.004146342,0.0003852956,0.002484122,0.001281606,0.00165316,0.003323404],"category_scores_gemma":[0.1036609,0.000825665,0.01266691,0.004500659,0.0009315423,0.001813592,0.001512104,0.002184609,0.0003009283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002416744,"about_ca_system_score_gemma":0.003745376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002529448,"about_ca_topic_score_gemma":0.00726814,"domain_scores_codex":[0.9693044,0.01440202,0.01031933,0.002156019,0.003367375,0.0004507638],"domain_scores_gemma":[0.8933101,0.09040862,0.01156239,0.001128762,0.003216289,0.0003739698],"domain_codex":null,"domain_gemma":"reporting","domain_candidate":"reporting","domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.002937244,0.00002817501,0.001435108,0.8023247,0.07153202,0.00004248048,0.0001255514,0.0003053052,0.000357147,0.0004486382,0.002632567,0.1178312],"study_design_scores_gemma":[0.004874869,0.001199823,0.01216398,0.5006042,0.442493,0.0003484066,0.0002302168,0.0002409327,0.0007329895,0.001768233,0.03525175,0.00009157708],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008829379,0.9977343,0.0002096767,0.0002053976,0.0002254058,0.0001539274,0.0003254261,0.00001004942,0.0002528856],"genre_scores_gemma":[0.0347895,0.9609836,0.001123912,0.001521339,0.0003159941,0.0005699003,0.0004989312,0.00002076735,0.000176151],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9907158,"threshold_uncertainty_score":0.134708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1272674042778694,"score_gpt":0.4600022332855313,"score_spread":0.3327348290076619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}