{"id":"W4379769380","doi":"10.1210/endocr/bqad089","title":"Organophosphate Esters Disrupt Steroidogenesis in KGN Human Ovarian Granulosa Cells","year":2023,"lang":"en","type":"article","venue":"Endocrinology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Health Canada; Fukuoka University; Université de Montréal; McGill University","keywords":"Chemistry; Triphenyl phosphate; Polybrominated diphenyl ethers; Organophosphate; Cholesterol side-chain cleavage enzyme; Internal medicine; Endocrinology; Downregulation and upregulation; Diphenyl ether; TCEP; Phosphate; Steroid biosynthesis; Steroid; Hormone; Fire retardant; Metabolism; Biochemistry; Cytochrome P450; Gene; Biology; Organic chemistry; Pesticide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000108859,0.0001834587,0.0002712697,0.0001713954,0.0001588889,0.0002850039,0.0001069402,0.0001882338,0.001117605],"category_scores_gemma":[0.0001051898,0.0001338408,0.0002769674,0.0002253285,0.0002171532,0.0001073498,0.0001900723,0.0002870004,0.000332669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000219789,"about_ca_system_score_gemma":0.0002765431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001928432,"about_ca_topic_score_gemma":0.002627434,"domain_scores_codex":[0.999846,0.00002047941,0.00002136674,0.00002521337,0.00005194235,0.00003504029],"domain_scores_gemma":[0.9999362,0.00001612998,0.00001537965,0.00001034473,0.00001118208,0.00001074506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003786012,0.00004764298,0.0009994387,0.0000964562,0.00000769105,0.000170739,0.00008621971,0.00006265473,0.9958111,0.00004246374,0.00008253028,0.002214398],"study_design_scores_gemma":[0.00006090898,0.0007605397,0.03034133,0.00002642965,0.00003257873,0.0005137248,0.0004003177,0.000519608,0.9592863,0.00007947379,0.007970476,0.000008277244],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926958,0.003737831,0.0006923391,0.0001726672,0.00005030199,0.00004252934,0.0009069348,0.00003451549,0.001667131],"genre_scores_gemma":[0.9916884,0.002708929,0.001269513,0.0001975178,0.00001387648,0.0000653045,0.00108772,0.00001050769,0.002958223],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001928432,"threshold_uncertainty_score":0.003834426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008601624282745643,"score_gpt":0.2539541904261681,"score_spread":0.2453525661434224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}