{"id":"W4379780265","doi":"10.1126/science.abo2296","title":"A microbiota-modulated checkpoint directs immunosuppressive intestinal T cells into cancers","year":2023,"lang":"en","type":"article","venue":"Science","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":221,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Agence Nationale de la Recherche","keywords":"Addressin; Immunology; Immunosuppression; Biology; Immune system; ABX test; Immunosurveillance; Cancer research; Immune checkpoint; Integrin; Receptor; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007693687,0.0001999814,0.0001483886,0.000134525,0.0001073003,0.0002810484,0.00006982468,0.0001822581,0.001447197],"category_scores_gemma":[0.0001247531,0.00007024684,0.0001209967,0.00005703874,0.0001163648,0.0001666593,0.0002184792,0.000464714,0.0002184769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001466809,"about_ca_system_score_gemma":0.0001426458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001013357,"about_ca_topic_score_gemma":0.0002306149,"domain_scores_codex":[0.9999319,0.0000148509,0.000004004207,0.00001056018,0.000009934629,0.00002875297],"domain_scores_gemma":[0.9999543,0.000004732518,0.00001371046,0.000004134458,0.000004411117,0.00001866037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008477623,0.0001773129,0.003415025,0.0001393117,0.00001594768,0.0002112858,0.00004532421,0.0001500006,0.9725032,0.0003597179,0.000373781,0.02176136],"study_design_scores_gemma":[0.0004183573,0.006950541,0.1190698,0.0001302679,0.0001232207,0.003892857,0.0005025407,0.003260626,0.842555,0.001208592,0.02187034,0.00001781386],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939396,0.003604056,0.0005271028,0.0001826479,0.00005154818,0.00002323383,0.00006154607,0.00005371677,0.001556528],"genre_scores_gemma":[0.9982157,0.000747523,0.0002687623,0.00006792627,0.00001895873,0.000009056663,0.00003855818,0.000003181262,0.0006302959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001447197,"threshold_uncertainty_score":0.004841387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01325237721439475,"score_gpt":0.2885801892448063,"score_spread":0.2753278120304116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}