{"id":"W4379791432","doi":"10.1021/acs.bioconjchem.3c00090","title":"Formal [4 + 2] Cycloadditions of Maleimides on Duplex DNA","year":2023,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Universität Zürich; Canada Foundation for Innovation; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Maleimide; Bioconjugation; Chemistry; Cycloaddition; DNA; Duplex (building); Combinatorial chemistry; Organic chemistry; Catalysis; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00008686916,0.0002410378,0.0002346779,0.00002808603,0.0001820546,0.00002402794,0.0003731325,0.000224939,0.005909655],"category_scores_gemma":[0.00009832561,0.0002549656,0.0001884193,0.0003371238,0.0001961344,0.00007686502,0.0001241733,0.0002255492,0.0003937303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000456998,"about_ca_system_score_gemma":0.00005582105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006899274,"about_ca_topic_score_gemma":5.07037e-7,"domain_scores_codex":[0.9985341,0.000003371157,0.0004054086,0.0003941844,0.0002358939,0.0004270147],"domain_scores_gemma":[0.9987553,0.0001468227,0.0001762171,0.0006936201,0.0000681879,0.0001597874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002561618,0.0001171967,0.0001254566,0.0004175261,0.00003692331,0.000008263652,0.00003565536,0.00003872121,0.9883438,0.0003650978,0.009813042,0.0006726562],"study_design_scores_gemma":[0.0004000291,0.000006030073,0.0001631687,0.0001010631,0.00002339209,0.00001383943,0.0002622323,0.0001335205,0.9557968,0.0003706271,0.04247889,0.0002503464],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8754195,0.00002109368,0.000004353825,0.0003988891,0.00002307272,0.00005547536,0.0008533278,0.0003437184,0.1228806],"genre_scores_gemma":[0.9845954,0.00007337085,0.00004799964,0.00004882942,0.0003045546,0.0001732187,0.001252532,0.00003496889,0.01346909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1094115,"threshold_uncertainty_score":0.9999903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0223737869421809,"score_gpt":0.2566096859160953,"score_spread":0.2342358989739144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}