{"id":"W4379791432","doi":"10.1021/acs.bioconjchem.3c00090","title":"Formal [4 + 2] Cycloadditions of Maleimides on Duplex DNA","year":2023,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Universität Zürich; Canada Foundation for Innovation; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Maleimide; Bioconjugation; Chemistry; Cycloaddition; DNA; Duplex (building); Combinatorial chemistry; Organic chemistry; Catalysis; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002718452,0.0007601641,0.0002738216,0.0002359708,0.000187135,0.0002269765,0.0003333341,0.0002062922,0.001625024],"category_scores_gemma":[0.0003242757,0.0002006206,0.0001706429,0.0002171689,0.0002706533,0.0002527519,0.0003512221,0.0004818903,0.0004132111],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000388006,"about_ca_system_score_gemma":0.0002408855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003481981,"about_ca_topic_score_gemma":0.0009244058,"domain_scores_codex":[0.9997998,0.00003702142,0.00001484418,0.00005000502,0.00005029662,0.00004796564],"domain_scores_gemma":[0.9998618,0.00004267044,0.00003852524,0.00001682716,0.00001900641,0.0000211582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005950688,0.00002518037,0.00007184981,0.0001171878,0.00001176887,0.00008727256,0.00006233081,0.000266658,0.9939902,0.0007192283,0.0000879776,0.004500938],"study_design_scores_gemma":[0.000005361319,0.0001153106,0.000212235,0.000002667482,0.000005003393,0.00007965388,0.000005303297,0.0002697091,0.9974595,0.00005353908,0.001786748,0.000005043241],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9456352,0.003612826,0.03995057,0.0001333635,0.00009530554,0.0002052045,0.000332553,0.0004451675,0.009589935],"genre_scores_gemma":[0.981126,0.0024921,0.01163739,0.00005460558,0.00002574563,0.0001148004,0.0002641049,0.00004952186,0.004235697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001625024,"threshold_uncertainty_score":0.005436242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0223737869421809,"score_gpt":0.2566096859160953,"score_spread":0.2342358989739144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}