{"id":"W4379791592","doi":"10.1038/s41598-023-36512-7","title":"Regulation of TRIB1 abundance in hepatocyte models in response to proteasome inhibition","year":2023,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Heart Research Centre; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Proteasome; Biology; Proteasome inhibitor; Cell biology; Downregulation and upregulation; Ubiquitin; Gene silencing; Small hairpin RNA; Biochemistry; Gene; Gene knockdown","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002507965,0.0003373781,0.0003979074,0.0003304985,0.0002279622,0.0003721465,0.0001551702,0.0002009729,0.001393823],"category_scores_gemma":[0.0001487461,0.0001178442,0.0002343802,0.0003081412,0.0002749937,0.000188446,0.0001863258,0.0006201974,0.000477503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002867463,"about_ca_system_score_gemma":0.0001782076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005054737,"about_ca_topic_score_gemma":0.0008433966,"domain_scores_codex":[0.9997587,0.00004887065,0.0000306108,0.00003963361,0.0000672426,0.00005498491],"domain_scores_gemma":[0.9998125,0.00003318814,0.00003980576,0.00003255079,0.00003277394,0.00004918515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002610551,0.00005360594,0.0001580917,0.00002767955,0.000003695411,0.00004954587,0.00002075631,0.00004670802,0.9987337,0.00004800584,0.00003783123,0.0005592842],"study_design_scores_gemma":[0.00001015506,0.0003561495,0.001544283,0.000001425879,0.000009535436,0.0001293777,0.00003190228,0.0005283222,0.9966162,0.00002535598,0.0007436495,0.000003838856],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990692,0.001436713,0.004984342,0.0001323302,0.00007761418,0.00005941948,0.0007498469,0.0001871065,0.001680682],"genre_scores_gemma":[0.9896802,0.001046469,0.003885502,0.00005101797,0.00001850108,0.0001059153,0.001059838,0.00004668609,0.0041058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001393823,"threshold_uncertainty_score":0.004662812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01287824354595306,"score_gpt":0.2582881518591508,"score_spread":0.2454099083131978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}