{"id":"W4379798883","doi":"10.1136/annrheumdis-2023-eular.2813","title":"POS1109 PUTATIVE ROLE OF THE HISTIDINE AND TRYPTOPHAN BIOCHEMICAL PATHWAYS IN THE MODE OF ACTION OF UPADACITINIB IN PATIENTS WITH ANKYLOSING SPONDYLITIS","year":2023,"lang":"en","type":"article","venue":"","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"The Metabolomics Innovation Centre; University of Alberta","funders":"Medac; Celgene; Gilead Sciences; Chugai Pharmaceutical; Amgen; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; Sun Pharma; Biogen; GlaxoSmithKline","keywords":"Ankylosing spondylitis; Medicine; Mode of action; Tryptophan; Spondylitis; Pharmacology; Immunology; Biochemistry; Amino acid; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001417132,0.0002645406,0.000338721,0.0003325827,0.0001445572,0.0003655899,0.0001591984,0.0002335858,0.002558447],"category_scores_gemma":[0.0001982037,0.00009909318,0.0002458502,0.0003408881,0.0001351969,0.0001383294,0.0001526537,0.0002302069,0.0003846487],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002387984,"about_ca_system_score_gemma":0.0002088273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000580527,"about_ca_topic_score_gemma":0.0008634129,"domain_scores_codex":[0.999922,0.0000166484,0.000009786006,0.00001998254,0.00001680695,0.00001476748],"domain_scores_gemma":[0.9999243,0.00001256437,0.0000302628,0.000004171427,0.000008834459,0.00001985635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02439833,0.0007226254,0.5435823,0.0004645678,0.0004602738,0.005960338,0.000183005,0.0009242422,0.3302822,0.0003467406,0.001848322,0.09082709],"study_design_scores_gemma":[0.000382073,0.00319321,0.9561295,0.00003908127,0.000356422,0.004912651,0.0001803615,0.003583547,0.02800002,0.0004326148,0.002768168,0.00002223045],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963226,0.001472071,0.0003113963,0.0001023506,0.00001716087,0.00002214579,0.0007485086,0.00001669324,0.0009871181],"genre_scores_gemma":[0.9984561,0.0003121105,0.0003436049,0.00007107436,0.00001678246,0.00001234875,0.0005264272,0.000003412594,0.0002580592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002558447,"threshold_uncertainty_score":0.00855881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02023681558396074,"score_gpt":0.2499172965643369,"score_spread":0.2296804809803762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}