{"id":"W4379800129","doi":"10.1136/annrheumdis-2023-eular.2612","title":"POS1122 EFFICACY AND SAFETY OF UPADACITINIB IN PATIENTS WITH ACTIVE ANKYLOSING SPONDYLITIS AND AN INADEQUATE RESPONSE TO BIOLOGIC DMARD THERAPY: ONE-YEAR RESULTS FROM A PHASE 3 STUDY","year":2023,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Arthritis Society; University of Toronto; University Health Network","funders":"","keywords":"Medicine; Ankylosing spondylitis; Internal medicine; Placebo; Imputation (statistics); Adverse effect; Clinical endpoint; Clinical trial; Gastroenterology; Physical therapy; Missing data","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001895769,0.001365155,0.003169686,0.0003584019,0.0004957958,0.001534594,0.000617685,0.001538754,0.002693071],"category_scores_gemma":[0.001157078,0.0005369438,0.002525733,0.000542724,0.0009678787,0.001586757,0.000317137,0.003380778,0.0009948105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007160665,"about_ca_system_score_gemma":0.0007619366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005975566,"about_ca_topic_score_gemma":0.001342115,"domain_scores_codex":[0.9993487,0.0002869144,0.00004566406,0.0001117752,0.0000704578,0.0001365592],"domain_scores_gemma":[0.9991259,0.0002451177,0.0002022662,0.00007622972,0.00007101408,0.0002795786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8704574,0.01451365,0.01358072,0.0008719705,0.003353896,0.0003535071,0.0001580712,0.002123417,0.01601957,0.0001552858,0.002671504,0.07574106],"study_design_scores_gemma":[0.5790157,0.3479778,0.06108363,0.0001073664,0.002493954,0.0009138082,0.0001634236,0.001908131,0.003359511,0.0002671487,0.002575255,0.0001341787],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947345,0.002870133,0.0001479635,0.000199163,0.00007321161,0.0002306503,0.0008134343,0.00004816537,0.0008828618],"genre_scores_gemma":[0.9949777,0.00131554,0.0002584913,0.0004887931,0.00007877062,0.0002269222,0.001884287,0.0000186273,0.0007509771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003169686,"threshold_uncertainty_score":0.01002592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05700709635118935,"score_gpt":0.3467643609029913,"score_spread":0.289757264551802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}