{"id":"W4379801286","doi":"10.1136/annrheumdis-2023-eular.3708","title":"POS1111 TREATMENT WITH UPADACITINIB RESULTS IN THE INHIBITION OF A BROAD RANGE OF POTENTIALLY PATHOGENIC PATHWAYS IN NR-AXSPA AND BDMARD-IR AS PATIENTS: PROTEOMIC ANALYSIS FROM THE SELECT-AXIS 2 PHASE 3 STUDIES","year":2023,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Digestive system and related health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Mitacs","keywords":"Medicine; Axial spondyloarthritis; Immunology; Bioinformatics; Ankylosing spondylitis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008402983,0.0004300856,0.0005510799,0.0002518489,0.0002611241,0.0007884604,0.0001823065,0.0003231221,0.002358983],"category_scores_gemma":[0.0003377165,0.000146345,0.0006333581,0.0002420454,0.0002394525,0.0003343557,0.0001818374,0.0007292563,0.0004315908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002956412,"about_ca_system_score_gemma":0.0003390245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002974187,"about_ca_topic_score_gemma":0.0008598411,"domain_scores_codex":[0.9998314,0.00003905982,0.00001463395,0.00003480074,0.00004309005,0.00003683506],"domain_scores_gemma":[0.999833,0.00003319778,0.00003862592,0.00001611051,0.0000273153,0.00005179076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.09824438,0.003010427,0.1179543,0.0009538179,0.002017549,0.001315396,0.0001942964,0.001518048,0.5311299,0.0007615793,0.008182237,0.2347181],"study_design_scores_gemma":[0.01261578,0.06021946,0.7731158,0.0002437158,0.002403393,0.007854332,0.0006817743,0.002960477,0.1018577,0.001214772,0.03671993,0.0001127925],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918783,0.003504768,0.0004767307,0.0003650135,0.00008339318,0.00009797989,0.001147847,0.00004948824,0.002396465],"genre_scores_gemma":[0.9931502,0.001444896,0.0008530253,0.00048847,0.00004573919,0.00008327443,0.002834721,0.0000153445,0.001084471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002358983,"threshold_uncertainty_score":0.007891536,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03239215306827038,"score_gpt":0.3102956881162539,"score_spread":0.2779035350479835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}