{"id":"W4379801286","doi":"10.1136/annrheumdis-2023-eular.3708","title":"POS1111 TREATMENT WITH UPADACITINIB RESULTS IN THE INHIBITION OF A BROAD RANGE OF POTENTIALLY PATHOGENIC PATHWAYS IN NR-AXSPA AND BDMARD-IR AS PATIENTS: PROTEOMIC ANALYSIS FROM THE SELECT-AXIS 2 PHASE 3 STUDIES","year":2023,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Digestive system and related health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Mitacs","keywords":"Medicine; Axial spondyloarthritis; Immunology; Bioinformatics; Ankylosing spondylitis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004062589,0.0001518492,0.0003847723,0.00009522165,0.0000609354,0.000008123629,0.0001517397,0.00005410147,0.000001813084],"category_scores_gemma":[0.0003191074,0.00006913696,0.0001721283,0.0005768597,0.0001516666,0.000007611548,0.00006231129,0.00004292469,6.930038e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001034813,"about_ca_system_score_gemma":0.0001222043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008811056,"about_ca_topic_score_gemma":0.0004232721,"domain_scores_codex":[0.9983437,0.0004821209,0.0005451005,0.0002241494,0.0002366569,0.000168253],"domain_scores_gemma":[0.9988483,0.0001511609,0.0004384789,0.0003650035,0.0001637361,0.00003337087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02091298,0.01316256,0.7353348,0.002737664,0.01855948,0.00004881067,0.05425327,0.003047946,0.05888606,0.0002562263,0.002619623,0.09018059],"study_design_scores_gemma":[0.008211437,0.003646248,0.9604912,0.001701891,0.0009147828,0.000002006075,0.005458844,0.0001456293,0.01852299,0.0006481693,0.00003113842,0.0002256973],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945237,0.002913837,0.000003645966,0.000539569,0.00001755812,0.0009375181,0.001022851,0.000003994649,0.00003732989],"genre_scores_gemma":[0.995419,0.004168803,0.000009427059,0.00006210739,0.000008220546,0.00009190148,0.0002164744,0.000008814859,0.00001521297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2251564,"threshold_uncertainty_score":0.2819323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03239215306827038,"score_gpt":0.3102956881162539,"score_spread":0.2779035350479835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}