{"id":"W4379877956","doi":"10.1038/s41588-023-01408-9","title":"Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake","year":2023,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Steno Diabetes Center Aarhus; Common Fund; National Institute of Neurological Disorders and Stroke; Abbott Diagnostics; Bayer; National Cancer Institute; Quest Diagnostics; National Institute on Aging; Bayer Vital; National Institutes of Health; NIH Office of the Director; Novo Nordisk Fonden; Steno Diabetes Center Copenhagen; Danone; National Institute of General Medical Sciences; National Institute on Drug Abuse; Novo Nordisk; National Human Genome Research Institute; National Institute of Diabetes and Digestive and Kidney Diseases; Sanofi; National Center for Advancing Translational Sciences; Medical Research Council; AstraZeneca; National Institute of Mental Health; National Heart, Lung, and Blood Institute; Pfizer; Amgen","keywords":"Biology; Genome-wide association study; Candidate gene; Gene; Genetics; Genetic association; Insulin; Genome; Computational biology; Single-nucleotide polymorphism; Biotechnology; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001561797,0.0006197356,0.000383981,0.001855942,0.0004149899,0.0007738686,0.000829496,0.000859086,0.001525141],"category_scores_gemma":[0.002137508,0.0003892304,0.0009357638,0.001970164,0.0004941277,0.000278129,0.0004982727,0.0009612733,0.0002482351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002093277,"about_ca_system_score_gemma":0.0002873323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002679683,"about_ca_topic_score_gemma":0.001871168,"domain_scores_codex":[0.9990439,0.0004335693,0.00009601847,0.0002271486,0.0001196003,0.00007980056],"domain_scores_gemma":[0.9980369,0.0009552609,0.0004388908,0.0001991849,0.0001521338,0.0002175723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002962748,0.0002370628,0.9551041,0.00005697537,0.001277292,0.001079857,0.0001561596,0.0002534707,0.03208582,0.0004250024,0.0002809126,0.006080663],"study_design_scores_gemma":[0.00007780619,0.0001827305,0.9933702,0.000007858785,0.0004547426,0.001261194,0.0001160013,0.001391551,0.002475083,0.0003034678,0.0003472063,0.00001216958],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967641,0.000623339,0.001598236,0.0001702565,0.00002282881,0.000009843694,0.0003313171,0.00002516777,0.0004550267],"genre_scores_gemma":[0.9983399,0.0001584377,0.000823324,0.0000415224,0.0000190866,0.000009270998,0.0002750554,0.00001055289,0.0003228383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002679683,"threshold_uncertainty_score":0.008259654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01192179507744932,"score_gpt":0.2653770551241635,"score_spread":0.2534552600467142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}