{"id":"W4379878284","doi":"10.1038/s41467-023-39042-y","title":"B cell profiles, antibody repertoire and reactivity reveal dysregulated responses with autoimmune features in melanoma","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Guy's and St Thomas' NHS Foundation Trust; Menzies Centre for Australian Studies, King's College London, University of London; Biotechnology and Biological Sciences Research Council; Medical Research Council; King's Health Partners; King's College London; Guy's and St Thomas' Charity; Rotary Foundation; Cancer Research UK; National Institute for Health and Care Research; Breast Cancer Now","keywords":"Antibody; Repertoire; Melanoma; Immunology; Computational biology; Cell; Biology; Medicine; Cancer research; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001273901,0.0001244313,0.0001291046,0.0007630755,0.0001301384,0.0002390973,0.00006006214,0.0001815044,0.001052413],"category_scores_gemma":[0.000181244,0.00008562367,0.00008939024,0.0002406082,0.0001109255,0.0001006595,0.0001328907,0.0001617132,0.0001911306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006390204,"about_ca_system_score_gemma":0.0000508891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000297706,"about_ca_topic_score_gemma":0.0003621267,"domain_scores_codex":[0.999907,0.0000177527,0.000008536949,0.00003021924,0.00001790264,0.00001858504],"domain_scores_gemma":[0.9999052,0.00001501785,0.00002959067,0.00001096399,0.00001406986,0.00002520671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005046972,0.00004594821,0.2038348,0.00005863038,0.00003963844,0.000451797,0.0002283024,0.00008147774,0.7848203,0.00005651328,0.0001094251,0.009768535],"study_design_scores_gemma":[0.000007076699,0.0003570074,0.9597132,0.00001164026,0.00004219192,0.004405832,0.0002016871,0.0003435304,0.03385009,0.0001150257,0.0009482566,0.00000445972],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987086,0.00052221,0.0002710859,0.000008830578,0.000001707093,0.000003137139,0.0001021516,0.00001410646,0.0003682881],"genre_scores_gemma":[0.9993452,0.000135202,0.0002050894,0.0000159035,0.000003734384,0.000003250631,0.00009267267,0.000003582411,0.0001954006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001052413,"threshold_uncertainty_score":0.003520668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01116157518310993,"score_gpt":0.2809874475401685,"score_spread":0.2698258723570585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}