{"id":"W4379878284","doi":"10.1038/s41467-023-39042-y","title":"B cell profiles, antibody repertoire and reactivity reveal dysregulated responses with autoimmune features in melanoma","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Guy's and St Thomas' NHS Foundation Trust; Menzies Centre for Australian Studies, King's College London, University of London; Biotechnology and Biological Sciences Research Council; Medical Research Council; King's Health Partners; King's College London; Guy's and St Thomas' Charity; Rotary Foundation; Cancer Research UK; National Institute for Health and Care Research; Breast Cancer Now","keywords":"Antibody; Repertoire; Melanoma; Immunology; Computational biology; Cell; Biology; Medicine; Cancer research; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006970487,0.0002689497,0.0003837405,0.0004490313,0.0006265815,0.00003932759,0.000789406,0.0007289551,0.00002960976],"category_scores_gemma":[0.0002657704,0.000219216,0.00006260497,0.0009877753,0.0005892323,0.0001993804,0.0003679817,0.00180093,0.00006873292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005796949,"about_ca_system_score_gemma":0.0001673195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002884279,"about_ca_topic_score_gemma":0.0002363309,"domain_scores_codex":[0.9976687,0.001157491,0.0003327915,0.0003641024,0.00006340644,0.000413459],"domain_scores_gemma":[0.9966706,0.001112728,0.0001696553,0.001922923,0.000105198,0.00001886965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002038366,0.0002732098,0.0141052,0.00002281509,0.0001198417,0.00001816456,0.001041755,0.000001668345,0.9708923,0.0007912201,0.006425504,0.004269932],"study_design_scores_gemma":[0.001826202,0.0002446702,0.8122248,0.0001552729,0.00003305272,0.0002049961,0.0005326519,0.000009591704,0.06988124,0.00006003021,0.1144958,0.000331697],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9123497,0.080378,0.000001795081,0.004757214,0.0001592008,0.0005064452,0.00006468886,0.0003031599,0.001479804],"genre_scores_gemma":[0.9815454,0.004167757,0.0003155004,0.0001618031,0.000007067637,0.00008335766,0.0008270572,0.0000397001,0.01285231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9010111,"threshold_uncertainty_score":0.8939369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01116157518310993,"score_gpt":0.2809874475401685,"score_spread":0.2698258723570585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}